预后营养指数、老年营养风险指数及全身炎症指标在接受放疗的IIB-III期宫颈癌患者中的预后价值
Prognostic values of the prognostic nutritional index, geriatric nutritional risk index, and systemic inflammatory indexes in patients with stage IIB-III cervical cancer receiving radiotherapy.
作者信息
Wang Hong-Bing, Xu Xin-Tian, Tian Meng-Xing, Ding Chen-Chen, Tang Jing, Qian Yu, Jin Xin
机构信息
Department of Gynecology and Oncology, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Department of Pharmacy, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
出版信息
Front Nutr. 2023 Mar 2;10:1000326. doi: 10.3389/fnut.2023.1000326. eCollection 2023.
BACKGROUND
Growing evidence suggests that nutritional status and inflammation are associated with survival in various cancers. This study aimed to evaluate the prognostic value of the prognostic nutritional index (PNI), geriatric nutritional risk index (GNRI), and systemic inflammatory indexes (neutrophil/lymphocyte ratio [NLR], monocyte/lymphocyte ratio [MLR], and platelet/lymphocyte ratio [PLR]) in patients with stage IIB-III cervical cancer receiving radiotherapy.
RESULTS
The ideal cutoff values for the PNI, GNRI, NLR, MLR, and PLR were 48.3, 97.04, 2.8, 0.41, and 186.67, respectively. Low PNI and GNRI scores were associated with poor OS and PFS. High NLR, MLR, and PLR also predicted inferior 5-year OS and PFS rates in patients with stage IIB-III cervical cancer. Multivariate Cox regression analysis identified tumor size, histological type, stage, number of metastatic lymph nodes, PNI, GNRI, NLR, PLR, and MLR as significant prognostic factors for OS and PFS.
CONCLUSIONS
The current findings suggest that the PNI, GNRI, NLR, PLR, and MLR are essential parameters for predicting prognosis in patients with stage IIB-III cervical cancer receiving radiotherapy.
背景
越来越多的证据表明，营养状况和炎症与多种癌症的生存率相关。本研究旨在评估预后营养指数（PNI）、老年营养风险指数（GNRI）和全身炎症指标（中性粒细胞/淋巴细胞比值[NLR]、单核细胞/淋巴细胞比值[MLR]和血小板/淋巴细胞比值[PLR]）对接受放疗的IIB-III期宫颈癌患者的预后价值。
结果
PNI、GNRI、NLR、MLR和PLR的理想临界值分别为48.3、97.04、2.8、0.41和186.67。低PNI和GNRI评分与较差的总生存期（OS）和无进展生存期（PFS）相关。高NLR、MLR和PLR也预示着IIB-III期宫颈癌患者的5年OS和PFS率较低。多因素Cox回归分析确定肿瘤大小、组织学类型、分期、转移淋巴结数量、PNI、GNRI、NLR、PLR和MLR是OS和PFS的重要预后因素。
结论
目前的研究结果表明，PNI、GNRI、NLR、PLR和MLR是预测接受放疗的IIB-III期宫颈癌患者预后的重要参数。
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