Tuo Jinmei, Peng Yan, Linghu Yushuang, Tao Ming, Huang Shiming, Xu Zucai
Department of Neurology, Affiliated Hospital of Zunyi Medical University, Zunyi, China.
Department of Nursing, Affiliated Hospital of Zunyi Medical University, Zunyi, China.
Front Pharmacol. 2023 Mar 7;14:1091879. doi: 10.3389/fphar.2023.1091879. eCollection 2023.
Medicines from natural products can not only treat neurodegenerative diseases but also improve the cognitive dysfunction caused by treatments with western medicines. This study reviews the literature related to the regulation of mitochondrial participation in cognitive function by natural products. In this study, we focused on English articles in PubMed, Web of Science, and Google Scholar, from 15 October 2017, to 15 October 2022. Fourteen studies that followed the inclusion criteria were integrated, analyzed, and summarized. Several studies have shown that natural products can improve or reduce cognitive dysfunction by ameliorating mitochondrial dysfunction. These results suggest that natural products may serve as new therapeutic targets for neurodegenerative diseases.
天然产物药物不仅可以治疗神经退行性疾病,还可以改善西药治疗引起的认知功能障碍。本研究综述了与天然产物调节线粒体参与认知功能相关的文献。在本研究中,我们重点关注了2017年10月15日至2022年10月15日期间发表在PubMed、科学网和谷歌学术上的英文文章。对符合纳入标准的14项研究进行了整合、分析和总结。多项研究表明,天然产物可以通过改善线粒体功能障碍来改善或减轻认知功能障碍。这些结果表明,天然产物可能成为神经退行性疾病的新治疗靶点。