Ahonen Matti, Syvänen Johanna, Helenius Linda, Mattila Mikko, Perokorpi Tanja, Diarbakerli Elias, Gerdhem Paul, Helenius Ilkka
Department of Pediatric Surgery, Orthopedics and Traumatology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Department of Pediatric Orthopedics, University of Turku and Turku University Hospital, Turku, Finland.
Spine (Phila Pa 1976). 2023 May 15;48(10):665-671. doi: 10.1097/BRS.0000000000004641. Epub 2023 Mar 22.
Comparative cohort study.
The aim of the present study was to evaluate pain and health-related quality of life (HRQoL) in surgically managed patients with a minimum follow-up of 10 years compared with patients with untreated adolescent idiopathic scoliosis (AIS) and a healthy control group.
Posterior spinal fusion with pedicle screws is the standard treatment for AIS, although it remains unclear whether this procedure results in improved long-term HRQoL compared with untreated patients with AIS.
Sixty-four consecutive patients at a minimum follow-up of 10 years, who underwent posterior pedicle screw instrumentation for AIS were prospectively enrolled. Fifty-three (83%) of these patients completed Scoliosis Research Society (SRS) 24 questionnaires, clinical examination, and standing spinal radiographs. Pain and HRQoL were compared with age and sex-matched patients with untreated AIS and healthy individuals.
The mean major curve was 57° preoperatively and 15° at the 10-year follow-up. SRS-24 self-image domain score showed a significant improvement from preoperative to 2 years and remained significantly better at the 10-year follow-up ( P < 0.001). Patients fused to L3 or below had lower pain, satisfaction, and total score than patients fused to L2 or above ( P < 0.05), but self-image, function, and activity scores did not differ between groups at 10-year follow-up. Pain, self-image, general activity, and total SRS domains were significantly better at 10-year follow-up in the surgically treated patients as compared with untreated patients (all P < 0.05). Healthy controls had significantly higher total score s than those surgically treated at 10-year follow-ups ( P < 0.001).
Patients undergoing segmental pedicle screw instrumentation for AIS maintain high-level HRQoL during a 10-year follow-up. Their HRQoL was significantly better than in the untreated patients with AIS, except for the function domain. However, HRQoL remained at a lower level than in healthy controls.
比较队列研究。
本研究的目的是评估手术治疗且至少随访10年的患者的疼痛及健康相关生活质量(HRQoL),并与未治疗的青少年特发性脊柱侧凸(AIS)患者及健康对照组进行比较。
尽管与未治疗的AIS患者相比,后路椎弓根螺钉脊柱融合术是否能改善长期HRQoL仍不明确,但该手术是AIS的标准治疗方法。
前瞻性纳入64例连续接受AIS后路椎弓根螺钉内固定术且至少随访10年的患者。其中53例(83%)患者完成了脊柱侧凸研究学会(SRS)24项问卷、临床检查及站立位脊柱X线片检查。将疼痛和HRQoL与年龄及性别匹配的未治疗AIS患者和健康个体进行比较。
术前平均主弯角度为57°,10年随访时为15°。SRS - 24自我形象领域评分从术前到2年有显著改善,在10年随访时仍显著更好(P < 0.001)。融合至L3或更低节段的患者比融合至L2或更高节段的患者疼痛、满意度及总分更低(P < 0.05),但在10年随访时两组间自我形象、功能及活动评分无差异。与未治疗患者相比,手术治疗患者在10年随访时疼痛、自我形象、一般活动及SRS各领域总分均显著更好(均P < 0.05)。健康对照组在10年随访时总分显著高于手术治疗患者(P < 0.001)。
接受AIS节段性椎弓根螺钉内固定术的患者在10年随访期间维持较高水平的HRQoL。除功能领域外,他们的HRQoL显著优于未治疗的AIS患者。然而,HRQoL仍低于健康对照组。