S和Se杂环对髓系白血病细胞系PLB-985的细胞及细胞毒性作用的研究
A study on the cellular and cytotoxic effects of S and Se heterocycles on the myeloid leukemia cell line PLB-985.
作者信息
Auld Niccole, Flood Krystal, Kesharwani Tanay, Cavnar Peter J
机构信息
Department of Biology, University of West Florida, 11000 University Pkwy, Pensacola, FL, USA.
Department of Chemistry, University of West Florida, 11000 University Pkwy, Pensacola, FL, USA.
出版信息
Phosphorus Sulfur Silicon Relat Elem. 2022;197(8):876-884. doi: 10.1080/10426507.2022.2085272. Epub 2022 Jun 9.
Abstract
This paper describes the synthesis of several halogenated S and Se heterocycles and tests their biological activity by measuring the effects on the myeloid leukemia cell line, PLB-985 cells. We report that select compounds exhibit significant increases in mitochondria membrane potential and increased oxidative stress in PLB-985 cells. Our results contribute to the foundational knowledge of different S and Se containing compounds and their possible impacts on human cells.
摘要
本文描述了几种卤代硫和硒杂环化合物的合成，并通过测量对髓系白血病细胞系PLB - 985细胞的影响来测试它们的生物活性。我们报告称，特定化合物可使PLB - 985细胞的线粒体膜电位显著增加，并增强氧化应激。我们的结果有助于了解含硫和含硒化合物的基础知识及其对人体细胞可能产生的影响。
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