原发性免疫性血小板减少症的表观遗传机制范围综述。

Scoping Review on Epigenetic Mechanisms in Primary Immune Thrombocytopenia.

机构信息

Department of Paediatric, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Cheras, Kuala Lumpur 56000, Malaysia.

Research Centre, Hospital Tunku Ampuan Besar Tuanku Aishah Rohani, UKM Specialist Children's Hospital, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Cheras, Kuala Lumpur 56000, Malaysia.

出版信息

Genes (Basel). 2023 Feb 23;14(3):555. doi: 10.3390/genes14030555.

DOI:10.3390/genes14030555

PMID:36980827

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10048672/

Abstract

Immune Thrombocytopenia (ITP) is an autoimmune blood disorder that involves multiple pathways responsible for the homeostasis of the immune system. Numerous pieces of literature have proposed the potential of immune-related genes as diagnostic and prognostic biomarkers, which mostly implicate the role of B cells and T cells in the pathogenesis of ITP. However, a more in-depth understanding is required of how these immune-related genes are regulated. Thus, this scoping review aims to collate evidence and further elucidate each possible epigenetics mechanism in the regulation of immunological pathways pertinent to the pathogenesis of ITP. This encompasses DNA methylation, histone modification, and non-coding RNA. A total of 41 studies were scrutinized to further clarify how each of the epigenetics mechanisms is related to the pathogenesis of ITP. Identifying epigenetics mechanisms will provide a new paradigm that may assist in the diagnosis and treatment of immune thrombocytopenia.

摘要

免疫性血小板减少症（ITP）是一种涉及多种负责免疫系统稳态的途径的自身免疫性血液疾病。大量文献提出了免疫相关基因作为诊断和预后生物标志物的潜力，这些生物标志物主要涉及 B 细胞和 T 细胞在 ITP 发病机制中的作用。然而，需要更深入地了解这些免疫相关基因是如何被调控的。因此，本范围综述旨在收集证据，并进一步阐明与 ITP 发病机制相关的免疫途径调控的每个可能的表观遗传学机制。这包括 DNA 甲基化、组蛋白修饰和非编码 RNA。共审查了 41 项研究，以进一步阐明每种表观遗传学机制与 ITP 发病机制的关系。鉴定表观遗传学机制将提供一个新的范例，可能有助于免疫性血小板减少症的诊断和治疗。