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隧道瓣与冠向瓣推进术联合结缔组织移植治疗多个牙龈退缩:一项多中心随机临床试验。

Tunnel vs. coronally advanced flap in combination with a connective tissue graft for the treatment of multiple gingival recessions: a multi-center randomized clinical trial.

机构信息

Section of Post-Graduate Periodontology, Faculty of Odontology, Department of Dental Clinical Specialties, University Complutense, Plaza Ramón Y Cajal, 3, 28040, Madrid, Spain.

Clínica Periodontal Antonio Bujaldón, Almería, Spain.

出版信息

Clin Oral Investig. 2023 Jul;27(7):3627-3638. doi: 10.1007/s00784-023-04975-7. Epub 2023 Mar 29.

Abstract

OBJECTIVE

To evaluate the efficacy of the partial-thickness non-advanced tunnel technique (TUN) versus the coronally advanced flap (CAF), both combined with a connective tissue graft, in the treatment of multiple gingival recessions.

MATERIALS AND METHODS

Twenty-nine patients (83 teeth) affected by multiple gingival recessions were treated in two clinical centers with either the test (TUN) or the control (CAF) intervention combined with a connective tissue graft. Outcomes at 3 and 6 months after surgery included complete root coverage (CRC-primary outcome), mean root coverage (mRC), changes in recession depth (RD), probing pocket depth (PPD), and keratinized tissue height (KT). Root sensitivity and root coverage esthetic score (RES) were also evaluated at 6-month examination. Surgery duration, wound healing index (WHI), and patient-reported outcome measures (PROMs) were additionally considered.

RESULTS

At 6 months, CRC was observed in 80.9% and 79.5% of the teeth treated with TUN and CAF, respectively (odds ratio = 1.2; p = 0.802). No differences between groups were also observed in terms of mRC (TUN = 94.0%; CAF = 91.1%), RD and PPD reductions, root sensitivity, RES, and WHI. KT increase was significantly higher in teeth treated with TUN (Difference in Means - MD =  - 1.0 mm; p = 0.001). Surgery duration was shorter (MD =  - 19.3 min; p = 0.001), and patients reported less intra-surgical pain (MD =  - 16.4; p = 0.028) as well as postoperative morbidity in TUN compared with CAF.

CONCLUSIONS

Both surgical interventions showed a similar efficacy in terms of root coverage, albeit TUN was associated with a higher increase in KT and with a milder patient's surgical experience.

CLINICAL RELEVANCE

Both techniques have shown similar efficacy for the coverage of exposed root surfaces, although clinicians may consider TUN as less invasive.

TRIAL REGISTRATION

Clinicaltrials.gov (NCT05122468).

摘要

目的

评估部分厚度非先进隧道技术(TUN)与冠向推进瓣(CAF)联合结缔组织移植治疗多发性牙龈退缩的疗效。

材料与方法

在两个临床中心,29 名(83 颗牙)患有多发性牙龈退缩的患者分别接受 TUN 或 CAF 联合结缔组织移植的治疗。术后 3 个月和 6 个月的评估指标包括完全根覆盖(CRC-主要结局)、平均根覆盖(mRC)、牙龈退缩深度(RD)变化、探诊袋深度(PPD)和角化组织高度(KT)。6 个月时还评估了根敏感和根覆盖美学评分(RES)。手术时间、伤口愈合指数(WHI)和患者报告的结果测量(PROMs)也被考虑在内。

结果

术后 6 个月,TUN 和 CAF 治疗的牙齿中,CRC 分别为 80.9%和 79.5%(比值比=1.2;p=0.802)。两组间 mRC(TUN=94.0%;CAF=91.1%)、RD 和 PPD 减少、根敏感、RES 和 WHI 无差异。TUN 治疗的牙齿 KT 增加明显更高(差异均数- MD=-1.0mm;p=0.001)。TUN 组手术时间较短(MD=-19.3min;p=0.001),患者术中疼痛(MD=-16.4;p=0.028)和术后发病率均低于 CAF 组。

结论

两种手术干预在根覆盖方面具有相似的疗效,尽管 TUN 与 KT 增加更高和患者手术体验更轻相关。

临床相关性

两种技术在暴露根面的覆盖方面均显示出相似的疗效,尽管临床医生可能认为 TUN 具有更小的侵入性。

临床试验注册

Clinicaltrials.gov(NCT05122468)。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f3e3/10329586/80e683595fc0/784_2023_4975_Fig1_HTML.jpg

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