补充维生素D对2型糖尿病生物标志物的影响：一项干预性荟萃分析汇总
Effect of vitamin D supplementation on type 2 diabetes biomarkers: an umbrella of interventional meta-analyses.
作者信息
Musazadeh Vali, Kavyani Zeynab, Mirhosseini Naghmeh, Dehghan Parvin, Vajdi Mahdi
机构信息
Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
出版信息
Diabetol Metab Syndr. 2023 Apr 19;15(1):76. doi: 10.1186/s13098-023-01010-3.
BACKGROUND
Vitamin D supplementation exerts several supporting effects on improving glycemic status, however, results are inconclusive. Thus, in the present study, we aimed to conduct an umbrella of meta-analysis regarding the impact of vitamin D on type 2 diabetes (T2DM) biomarkers.
METHODS
The Scopus, PubMed, Web of Science, Embase, and Google Scholar online databases were searched up to March 2022. All meta-analyses evaluating the impact of vitamin D supplementation on T2DM biomarkers were considered eligible. Overall, 37 meta-analyses were included in this umbrella meta-analysis.
RESULTS
Our findings indicated that vitamin D supplementation significantly decreased fasting blood sugar (FBS) (WMD = - 3.08; 95% CI: - 3.97, - 2.19, p < 0.001, and SMD = - 0.26; 95% CI: - 0.38, - 0.14, p < 0.001), hemoglobin A1c (HbA1c) (WMD = - 0.05; 95% CI: - 0.10, - 0.01, p = 0.016, and SMD = - 0.16; 95% CI: - 0.27, - 0.05, p = 0.004), insulin concentrations (WMD = - 2.62; 95% CI: - 4.11, - 1.13; p < 0.001, and SMD = - 0.33; 95% CI: - 0.56, - 0.11, p = 0.004), and homeostatic model assessment for insulin resistance (HOMA-IR) (WMD = - 0.67; 95% CI: - 1.01, - 0.32, p < 0.001, and SMD = - 0.31; 95% CI: - 0.46, - 0.16, p < 0.001).
CONCLUSION
This umbrella meta-analysis proposed that vitamin D supplementation may improve T2DM biomarkers.
背景
补充维生素D对改善血糖状况有多种辅助作用，然而，结果尚无定论。因此，在本研究中，我们旨在对维生素D对2型糖尿病（T2DM）生物标志物的影响进行一项汇总荟萃分析。
方法
检索了截至2022年3月的Scopus、PubMed、Web of Science、Embase和谷歌学术在线数据库。所有评估补充维生素D对T2DM生物标志物影响的荟萃分析均被视为合格。总体而言，本汇总荟萃分析纳入了37项荟萃分析。
结果
我们的研究结果表明，补充维生素D可显著降低空腹血糖（FBS）（加权均数差[WMD]= -3.08；95%置信区间[CI]：-3.97，-2.19，p<0.001，标准化均数差[SMD]= -0.26；95%CI：-0.38，-0.14，p<0.001）、糖化血红蛋白（HbA1c）（WMD= -0.05；95%CI：-0.10，-0.01，p=0.016，SMD= -0.16；95%CI：-0.27，-0.05，p=0.004）、胰岛素浓度（WMD= -2.62；95%CI：-4.11,-1.13；p<|FunctionExecuteBegin|>0.001<|FunctionExecuteEnd|>，SMD= -0.33；95%CI：-0.56，-0.11，p=0.004）以及胰岛素抵抗的稳态模型评估（HOMA-IR）（WMD= -0.67；95%CI：-1.01，-0.32，p<0.001，SMD= -0.31；95%CI：-0.46，-0.16，p<0.001）。
结论
本汇总荟萃分析表明，补充维生素D可能改善T2DM生物标志物。
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