客观而非主观的短睡眠时间失眠与高血压发病风险增加有关：睡眠心脏健康研究。

Insomnia with objective, but not subjective, short sleep duration is associated with increased risk of incident hypertension: the Sleep Heart Health Study.

机构信息

Department of Sleep Medicine, Shantou University Mental Health Center, Shantou University Medical College, Shantou, Guangdong, China.

Sleep Medicine Center, Shantou University Medical College, Shantou, Guangdong, China.

出版信息

J Clin Sleep Med. 2023 Aug 1;19(8):1421-1428. doi: 10.5664/jcsm.10570.

DOI:10.5664/jcsm.10570

PMID:37078185

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10394371/

Abstract

STUDY OBJECTIVES

Insomnia with objective short sleep duration has been associated with higher risk of cardiometabolic morbidity. In this study, we examined the association between insomnia with objective short sleep duration, also based on subjective sleep duration, with incident hypertension in the Sleep Heart Health Study.

METHODS

We analyzed data from 1,413 participants free of hypertension or sleep apnea at baseline from the Sleep Heart Health Study, with a median follow-up duration of 5.1 years. Insomnia symptoms were defined based on difficulty falling asleep, difficulty returning to sleep, early morning awakening, or sleeping pill use more than half the days in a month. Objective short sleep duration was defined as polysomnography-measured total sleep time < 6 hours. Incident hypertension was defined based on blood pressure measures and/or use of antihypertensive medications at follow-up.

RESULTS

Individuals with insomnia who slept objectively < 6 hours had significantly higher odds of incident hypertension compared to normal sleepers who slept ≥ 6 hours (odds ratio = 2.00, 95% confidence interval = 1.09-3.65) or < 6 hours (odds ratio = 2.00, 95% confidence interval = 1.06-3.79) or individuals with insomnia who slept ≥ 6 hours (odds ratio = 2.79, 95% confidence interval = 1.24-6.30). Individuals with insomnia who slept ≥ 6 hours or normal sleepers who slept < 6 hours were not associated with increased risk of incident hypertension compared to normal sleepers who slept ≥ 6 hours. Finally, individuals with insomnia who self-reported sleeping < 6 hours were not associated with significantly increased odds of incident hypertension.

CONCLUSIONS

These data further support that the insomnia with objective short sleep duration phenotype based on objective, but not subjective measures, is associated with increased risk of developing hypertension in adults.

CITATION

Dai Y, Chen B, Chen L, et al. Insomnia with objective, but not subjective, short sleep duration is associated with increased risk of incident hypertension: the Sleep Heart Health Study. . 2023;19(8):1421-1428.

摘要

研究目的

客观上睡眠时间短伴失眠与更高的心血管代谢发病风险相关。在本研究中，我们基于主观睡眠时间，使用客观睡眠数据，在睡眠心脏健康研究中检验了失眠与客观上睡眠时间短（<6 小时）伴失眠与新发高血压的相关性。

方法

我们分析了睡眠心脏健康研究中 1413 名基线时无高血压或睡眠呼吸暂停且中位随访时间为 5.1 年的参与者的数据。失眠症状定义为入睡困难、睡眠维持困难、早醒或每月半数以上天数使用助眠药物。客观上睡眠时间短定义为多导睡眠图测量的总睡眠时间<6 小时。新发高血压定义为随访时血压测量值和/或使用降压药物。

结果

与睡眠≥6 小时的正常睡眠者相比，客观上睡眠时间<6 小时的失眠者新发高血压的比值比显著更高（比值比=2.00，95%置信区间=1.09-3.65）或<6 小时（比值比=2.00，95%置信区间=1.06-3.79）或睡眠≥6 小时的失眠者（比值比=2.79，95%置信区间=1.24-6.30）。与睡眠≥6 小时的正常睡眠者相比，睡眠≥6 小时的失眠者或睡眠<6 小时的正常睡眠者均与新发高血压风险增加无关。最后，自我报告睡眠时间<6 小时的失眠者与新发高血压的比值比无显著增加。