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基于人群的成年人队列中,非自杀性自伤与自杀未遂的多方面风险。

Multifaceted risk for non-suicidal self-injury only versus suicide attempt in a population-based cohort of adults.

机构信息

Department of Psychiatry, Virginia Commonwealth University School of Medicine, Richmond 23298, VA, United States of America; Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond 23298, VA, United States of America.

Department of Psychiatry, Virginia Commonwealth University School of Medicine, Richmond 23298, VA, United States of America; Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond 23298, VA, United States of America.

出版信息

J Affect Disord. 2023 Jul 15;333:474-481. doi: 10.1016/j.jad.2023.04.040. Epub 2023 Apr 20.

Abstract

BACKGROUND

Non-suicidal self-injury and suicide attempt represent significant public health concerns. While these outcomes are related, there is prior evidence that their etiology does not entirely overlap. Efforts to directly differentiate risk across outcomes are uncommon, particularly among older, population-based cohorts.

METHODS

This research has been conducted using the UK Biobank. Data on individuals' self-reported history of non-suicidal self-injury only versus suicide attempt (maximum N = 6643) were analyzed. Applying LASSO and standard logistic regression, participants reporting one of these outcomes were assessed for differences across a range of sociodemographic, behavioral, and environmental features.

RESULTS

Sociodemographic features most strongly differentiated between the outcomes of non-suicidal self-injury only versus suicide attempt. Specifically, Black individuals were more likely to report a suicide attempt, as were those of mixed race, those endorsing higher levels of depressive symptoms or trauma history, and those who had experienced financial problems (odds ratios 1.02-3.92). Those more likely to engage in non-suicidal self-injury only were younger, female, had higher levels of education, those who resided with a partner, and those who had a recently injured relative.

LIMITATIONS

Differences in timing across correlates and outcomes preclude the ability to establish causal pathways.

CONCLUSIONS

The factors identified in the current study as differentially associated with non-suicidal self-injury only versus suicide attempt provide further evidence of at least partially distinct correlates, and warrant follow-up in independent samples to investigate causality.

摘要

背景

非自杀性自伤和自杀企图是重大的公共卫生问题。虽然这些结果相关,但有先前的证据表明,它们的病因并不完全重叠。直接区分不同结果的风险的努力并不常见,尤其是在年龄较大的、基于人群的队列中。

方法

本研究使用英国生物银行进行。仅分析了个人报告的非自杀性自伤史与自杀企图的历史数据(最大 N=6643)。应用 LASSO 和标准逻辑回归,对报告有这些结果之一的参与者进行了评估,以比较一系列社会人口统计学、行为和环境特征的差异。

结果

社会人口统计学特征最能区分非自杀性自伤与自杀企图的结果。具体而言,黑人更有可能报告自杀企图,混血儿也是如此,那些报告有更高水平的抑郁症状或创伤史的人也是如此,那些经历过经济问题的人也是如此(比值比 1.02-3.92)。更有可能仅进行非自杀性自伤的人更年轻、女性、受教育程度更高、与伴侣同住,以及最近有受伤亲属的人。

局限性

相关性和结果在时间上的差异排除了建立因果关系的能力。

结论

本研究确定的与非自杀性自伤仅与自杀企图相关的因素提供了至少部分不同的相关性的进一步证据,并需要在独立样本中进行随访以调查因果关系。

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