新型冠状病毒肺炎肺低氧血症的病理生理学。
Pathophysiology of Hypoxemia in COVID-19 Lung Disease.
机构信息
Division of Thoracic Surgery and Interventional Pulmonology, Beth Israel Deaconess Medical Center, Boston, MA, USA; Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Bulfinch 148, 55 Fruit Street, Boston, MA 02114, USA.
Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Bulfinch 148, 55 Fruit Street, Boston, MA 02114, USA.
出版信息
Clin Chest Med. 2023 Jun;44(2):239-248. doi: 10.1016/j.ccm.2022.11.007. Epub 2022 Nov 23.
As the pandemic has progressed, our understanding of hypoxemia in coronavirus disease 2019 (COVID-19) lung disease has become more nuanced, although much remains to be understood. In this article, we review ventilation-perfusion mismatching in COVID-19 and the evidence to support various biologic theories offered in explanation. In addition, the relationship between hypoxemia and other features of severe COVID-19 lung disease such as respiratory symptoms, radiographic abnormalities, and pulmonary mechanics is explored. Recognizing and understanding hypoxemia in COVID-19 lung disease remains essential for risk stratification, prognostication, and choice of appropriate treatments in severe COVID-19.
随着大流行的进展，我们对 2019 年冠状病毒病（COVID-19）肺部疾病中低氧血症的认识变得更加细致，但仍有许多问题有待了解。在本文中，我们回顾了 COVID-19 中的通气-灌注不匹配以及支持各种生物学理论的证据。此外，还探讨了低氧血症与严重 COVID-19 肺部疾病的其他特征（如呼吸症状、影像学异常和肺力学）之间的关系。认识和理解 COVID-19 肺部疾病中的低氧血症仍然是严重 COVID-19 中进行风险分层、预后判断和选择适当治疗的关键。
Zotero 插件