癌症免疫治疗中跨膜蛋白的二聚化

Dimerization of Transmembrane Proteins in Cancer Immunotherapy.

作者信息

Li Lei, Li Jingying

机构信息

College of Chemistry, Fuzhou University, Fuzhou 350108, China.

College of Biological Science and Engineering, Fuzhou University, Fuzhou 350108, China.

出版信息

Membranes (Basel). 2023 Mar 30;13(4):393. doi: 10.3390/membranes13040393.

DOI:10.3390/membranes13040393

PMID:37103820

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10143916/

Abstract

Transmembrane proteins (TMEMs) are integrated membrane proteins that span the entire lipid bilayer and are permanently anchored to it. TMEMs participate in various cellular processes. Some TMEMs usually exist and perform their physiological functions as dimers rather than monomers. TMEM dimerization is associated with various physiological functions, such as the regulation of enzyme activity, signal transduction, and cancer immunotherapy. In this review, we focus on the dimerization of transmembrane proteins in cancer immunotherapy. This review is divided into three parts. First, the structures and functions of several TMEMs related to tumor immunity are introduced. Second, the characteristics and functions of several typical TMEM dimerization processes are analyzed. Finally, the application of the regulation of TMEM dimerization in cancer immunotherapy is introduced.

摘要

跨膜蛋白（TMEMs）是整合膜蛋白，它们横跨整个脂质双层并永久锚定在其上。TMEMs参与各种细胞过程。一些TMEMs通常以二聚体而非单体的形式存在并发挥其生理功能。TMEM二聚化与多种生理功能相关，如酶活性调节、信号转导和癌症免疫治疗。在本综述中，我们聚焦于癌症免疫治疗中跨膜蛋白的二聚化。本综述分为三个部分。首先，介绍几种与肿瘤免疫相关的TMEMs的结构和功能。其次，分析几种典型TMEM二聚化过程的特点和功能。最后，介绍TMEM二聚化调控在癌症免疫治疗中的应用。