马肉瘤的免疫疗法——从早期方法到创新疫苗

Immunotherapy of Equine Sarcoids-From Early Approaches to Innovative Vaccines.

作者信息

Jindra Christoph, Hainisch Edmund K, Brandt Sabine

机构信息

Division of Molecular Oncology and Hematology, Karl Landsteiner University of Health Sciences, 3500 Krems an der Donau, Austria.

Research Group Oncology (RGO), Division of Equine Surgery, Department for Companion Animals and Horses, University of Veterinary Medicine, 1210 Vienna, Austria.

出版信息

Vaccines (Basel). 2023 Mar 30;11(4):769. doi: 10.3390/vaccines11040769.

DOI:10.3390/vaccines11040769

PMID:37112681

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10145708/

Abstract

Horses and other equid species are frequently affected by bovine papillomavirus type 1 and/or 2 (BPV1, BPV2)-induced skin tumors termed sarcoids. Although sarcoids do not metastasize, they constitute a serious health problem due to their BPV1/2-mediated resistance to treatment and propensity to recrudesce in a more severe, multiple form following accidental or iatrogenic trauma. This review provides an overview on BPV1/2 infection and associated immune escape in the equid host and presents early and recent immunotherapeutic approaches in sarcoid management.

摘要

马和其他马科动物经常受到1型和/或2型牛乳头瘤病毒（BPV1、BPV2）诱导的皮肤肿瘤——肉瘤样瘤的影响。尽管肉瘤样瘤不会转移，但由于其BPV1/2介导的对治疗的抗性以及在意外或医源性创伤后有以更严重、多发形式复发的倾向，它们构成了一个严重的健康问题。本综述概述了马科动物宿主中BPV1/2感染及相关的免疫逃逸情况，并介绍了肉瘤样瘤治疗中早期和近期的免疫治疗方法。