超声弹性成像联合血小板计数模型对肝纤维化的临床研究。

Clinical study on the evaluation of liver fibrosis by ultrasound elastography combined with platelet count model.

机构信息

School of Medicine, Nantong University, Nantong, China.

Department of Ultrasound Medicine, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.

出版信息

Clin Hemorheol Microcirc. 2023;84(2):205-214. doi: 10.3233/CH-231766.

DOI:10.3233/CH-231766

PMID:37125544

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10357194/

Abstract

OBJECTIVES

To establish the prediction model of liver fibrosis by combining ultrasound elastography and platelet count and evaluates its clinical value.

METHODS

146 patients with chronic liver diseases(CLD) admitted to our hospital from July 2020 to July 2022 were collected for liver biopsy pathological examination, and the results of ultrasound elastography (liver hardness value) and serological indicators were collected. Based on the results of Spearman correlation test and multiple linear regression model, the prediction model of liver fibrosis using ultrasound elastography combined with platelet count was constructed and verified.

RESULTS

The AUC of transient elastography combined with platelet count model (FSP) in the diagnosis of S2, S3 and S4 phases of liver fibrosis was 0.665, 0.835 and 0.909, with specificity of 81.5%, 90.0% and 100%. The AUC of sound touch elastography combined with platelet count model (STEP) in diagnosing S2, S3 and S4 phases of liver fibrosis was 0.685, 0.810 and 0884, with specificity of 96.3%, 90.0% and 83.3%, which are higher than APRI, FIB-4, FORNS, AAR and other models.

CONCLUSION

Ultrasound elastography combined with platelet count model has good diagnostic efficacy for liver fibrosis.

摘要

目的

通过联合超声弹性成像和血小板计数建立肝纤维化预测模型，并评价其临床价值。

方法

收集我院 2020 年 7 月至 2022 年 7 月收治的 146 例慢性肝病（CLD）患者进行肝活检病理检查，收集超声弹性成像（肝硬度值）和血清学指标的结果。基于 Spearman 相关检验和多元线性回归模型，构建并验证了联合超声弹性成像和血小板计数预测肝纤维化的模型。

结果

联合血小板计数模型的瞬时弹性成像（FSP）诊断肝纤维化 S2、S3 和 S4 期的 AUC 分别为 0.665、0.835 和 0.909，特异性分别为 81.5%、90.0%和 100%。联合血小板计数模型的声触诊组织弹性成像（STEP）诊断肝纤维化 S2、S3 和 S4 期的 AUC 分别为 0.685、0.810 和 0.884，特异性分别为 96.3%、90.0%和 83.3%，均高于 APRI、FIB-4、FORNS、AAR 等模型。