REV-ERB 核受体：核心时钟周期和代谢的定时钟。
The REV-ERB Nuclear Receptors: Timekeepers for the Core Clock Period and Metabolism.
机构信息
Institut National de la Santé et de la Recherche Médicale (INSERM) U1297, University of Toulouse 3, Toulouse, France.
Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
出版信息
Endocrinology. 2023 Apr 17;164(6). doi: 10.1210/endocr/bqad069.
Abstract
REV-ERB nuclear receptors are potent transcriptional repressors that play an important role in the core mammalian molecular clock and metabolism. Deletion of both REV-ERBα and its largely redundant isoform REV-ERBβ in a murine tissue-specific manner have shed light on their specific functions in clock mechanisms and circadian metabolism. This review highlights recent findings that establish REV-ERBs as crucial circadian timekeepers in a variety of tissues, regulating overlapping and distinct processes that maintain normal physiology and protect from metabolic dysfunction.
摘要
REV-ERB 核受体是强有力的转录抑制剂，在哺乳动物核心分子钟和代谢中发挥着重要作用。以鼠组织特异性方式删除 REV-ERBα及其主要冗余同种型 REV-ERBβ，揭示了它们在时钟机制和昼夜代谢中的特定功能。本综述重点介绍了最近的发现，这些发现将 REV-ERB 确立为各种组织中重要的昼夜节律计时者，调节维持正常生理和防止代谢功能障碍的重叠和不同过程。
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