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亚急性咳嗽的细菌病因学

Bacterial Etiology in Subacute Cough.

作者信息

Moon Ji-Yong, Lee Hyun, Kim Min-Hye, Song Woo-Jung, Lee Sang Min, Kim Sae-Hoon, Kim Sang-Heon, Lee Byung-Jae, Yoon Ho Joo, Kim Sang Hoon

机构信息

Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea.

Department of Internal Medicine, College of Medicine, Ewha Womans University, Seoul, Korea.

出版信息

Allergy Asthma Immunol Res. 2023 Sep;15(5):673-681. doi: 10.4168/aair.2023.15.5.673. Epub 2023 Apr 26.

Abstract

Although postinfectious etiology is the most common cause of subacute cough, there are insufficient data on the epidemiology of associated bacterial infections. We aimed to identify the etiology of bacterial detection in subjects with subacute cough. A multicenter prospective observational study of 142 patients with postinfectious subacute cough was performed between August 2016 and December 2017 in Korea. We obtained 2 nasal swabs from each patient and used a multiplex bacterial polymerase chain reaction (PCR) kit that simultaneously detects , , , , , and . About 29% (n = 41) of patients with subacute cough were positive for bacterial PCR in nasal swabs. The most common bacteria detected by bacterial PCR was (n = 19, 13.4%), followed by (n = 18, 12.7%), (n = 7, 4.9%), (n = 3, 2.1%), (n = 2, 1.4%), and (n = 1, 0.7%). Nine patients had dual positivity for the PCR. In conclusion, bacterial PCR was positive in the nasal swabs of about 29% of subjects with subacute cough, including 5% of positive PCR results for

摘要

虽然感染后病因是亚急性咳嗽最常见的原因,但关于相关细菌感染的流行病学数据不足。我们旨在确定亚急性咳嗽患者细菌检测的病因。2016年8月至2017年12月在韩国对142例感染后亚急性咳嗽患者进行了一项多中心前瞻性观察研究。我们从每位患者获取2份鼻拭子,并使用一种多重细菌聚合酶链反应(PCR)试剂盒,该试剂盒可同时检测 、 、 、 、 及 。约29%(n = 41)的亚急性咳嗽患者鼻拭子细菌PCR检测呈阳性。细菌PCR检测到的最常见细菌是 (n = 19,13.4%),其次是 (n = 18,12.7%)、 (n = 7,4.9%)、 (n = 3,2.1%)、 (n = 2,1.4%)和 (n = 1,0.7%)。9例患者PCR检测呈双重阳性。总之,约29%的亚急性咳嗽患者鼻拭子细菌PCR检测呈阳性,其中 阳性PCR结果占5%

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb3a/10570775/a1609f2a602b/aair-15-673-g001.jpg

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