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儿童新发呼吸道病毒谱分析。

Profile analysis of emerging respiratory virus in children.

机构信息

Microorganism Biotechnology Laboratory of Instituto de Patologia Tropical e Saúde Pública, Universidade Federal de Goiás, Goiânia, GO, Brazil.

Molecular Pathology Laboratory of Instituto de Ciências Biológicas II, Universidade Federal de Goiás, Goiânia, GO, Brazil.

出版信息

Eur J Clin Microbiol Infect Dis. 2023 Jul;42(7):873-882. doi: 10.1007/s10096-023-04615-8. Epub 2023 May 9.

Abstract

Acute respiratory infections (ARIs) are caused by a variety of microorganisms. Of all ARIs, 80% are caused by viruses such as human respiratory syncytial virus, metapneumovirus, influenza, parainfluenza, rhinovirus, and, more recently, Sars-CoV-2, which has been responsible for the COVID-19 pandemic. The objective of our study was to evaluate clinical data from a viral panel performed in children hospitalized with SARS or COVID-19 in the infirmary or ICU of 5 pediatric hospitals in the city of Goiânia, Goiás, Brazil. Demographic, clinical, and laboratory data were collected for analysis, and data on the outcomes underwent statistical treatment. A total of 128 patients were selected for the study, 54% of whom were male and 46% female. The viral panel included rhinovirus, COVID-19, metapneumovirus, adenovirus, and parainfluenza. Descriptive analyses of age profile showed differences in the involvement of particular viruses. The percentage of patients who required hospitalization in the ICU, infirmary, as well as individuals who were discharged after therapy or who died, were described. Our work shows that epidemiological surveillance measures are indispensable, especially if used in the continued analysis of viral panels in all pediatric patients with SARS.

摘要

急性呼吸道感染(ARI)由多种微生物引起。在所有 ARI 中,80%是由人类呼吸道合胞病毒、肺炎支原体、流感、副流感、鼻病毒和最近的 SARS-CoV-2 等病毒引起的,后者导致了 COVID-19 大流行。我们的研究目的是评估在巴西戈亚尼亚市 5 家儿科医院的医务室或 ICU 住院的 SARS 或 COVID-19 患儿进行的病毒组检测的临床数据。收集了人口统计学、临床和实验室数据进行分析,并对结局数据进行了统计学处理。共选择了 128 名患者进行研究,其中 54%为男性,46%为女性。病毒组包括鼻病毒、COVID-19、肺炎支原体、腺病毒和副流感。年龄分布的描述性分析显示出特定病毒参与的差异。描述了需要住院 ICU、医务室以及经治疗出院或死亡的患者比例。我们的工作表明,流行病学监测措施是必不可少的,特别是如果在所有 SARS 儿科患者中持续分析病毒组的话。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed57/10169160/c35297cdc136/10096_2023_4615_Fig1_HTML.jpg

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