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儿童糖尿病酮症酸中毒相关致命性脑静脉窦血栓形成。

Fatal cerebral sinus thrombosis associated with diabetic ketoacidosis in a child.

机构信息

Department of Forensic Medicine, Charles Nicolle Hospital, Tunis, Tunisia.

Department of Pathology, Charles Nicolle Hospital, Tunis, Tunisia.

出版信息

Forensic Sci Med Pathol. 2023 Jun;19(2):221-223. doi: 10.1007/s12024-023-00647-w. Epub 2023 May 24.

Abstract

Cerebral sinus thrombosis (CST) is an uncommon condition in children with a variable clinical presentation which has rarely been described in the setting of diabetic ketoacidosis. We present the case of 14-year-old child in whom lateral sinus thrombosis was caused by dehydration complicating ketoacidosis in a previously undiagnosed type 1 diabetes. The diagnosis of the CST was established during the autopsy due to the rapidity of the neurological deterioration. The cause of death was tonsillar herniation due to diffuse cerebral edema secondary to CST. This is the first published report of a CST in association with new onset type 1 diabetes in a child diagnosed at the postmortem examination.

摘要

脑窦血栓形成(CST)在儿童中较为少见,其临床表现多样,在糖尿病酮症酸中毒的情况下很少见。我们报告了一例 14 岁儿童的病例,该儿童因脱水并发未确诊的 1 型糖尿病而导致的酮症酸中毒引起外侧窦血栓形成。由于神经功能迅速恶化,在尸检期间确定了 CST 的诊断。由于 CST 引起的弥漫性脑水肿导致扁桃体疝,这是导致死亡的原因。这是首例在尸检时诊断为新发病的 1 型糖尿病患儿并发 CST 的病例。

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