木脂素摄入与心血管疾病和 2 型糖尿病风险：前瞻性队列研究的荟萃分析。

Lignan intake and risk of cardiovascular disease and type 2 diabetes: a meta-analysis of prospective cohort studies.

机构信息

Department of Cardiology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan Province, China.

Department of Pathology, The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Enshi, Hubei Province, China.

出版信息

Int J Food Sci Nutr. 2023;74(4):501-509. doi: 10.1080/09637486.2023.2220985. Epub 2023 Jun 6.

DOI:10.1080/09637486.2023.2220985

PMID:37282605

Abstract

We conducted a meta-analysis of 12 prospective cohort studies to further illuminate the associations of lignan intake with risk of cardiovascular disease (CVD) and type 2 diabetes mellitus (T2DM). Compared with the lowest intake, the highest intake of lignans was correlated with a decreased incidence of CVD (relative risk [RR]: 0.85, 95% confidence interval [CI]: 0.80-0.90) and T2DM (RR: 0.82, 95% CI: 0.68-0.99). The benefits of lignan intake in CVD prevention were consistent across subgroups. In dose-response analysis, the RR for every 500-μg/d increment in lignan intake was 0.83 (95% CI: 0.74-0.92) for CVD and 0.96 (95% CI: 0.95-0.98) for T2DM. Moreover, a curvilinear dose-response pattern was observed for both CVD ( for nonlinearity < 0.001) and T2DM ( for nonlinearity < 0.001) in relation to lignan intake. These results indicated that higher lignan intake may be associated, in a dose-dependent manner, with a lower risk of CVD and T2DM.

摘要

我们进行了一项荟萃分析，纳入了 12 项前瞻性队列研究，以进一步阐明木质素摄入量与心血管疾病（CVD）和 2 型糖尿病（T2DM）风险之间的关联。与最低摄入量相比，木质素摄入量最高与 CVD（相对风险 [RR]：0.85，95%置信区间 [CI]：0.80-0.90）和 T2DM（RR：0.82，95% CI：0.68-0.99）的发生率降低相关。木质素摄入对 CVD 预防的益处在亚组间是一致的。在剂量-反应分析中，木质素摄入量每增加 500μg/d，CVD 的 RR 为 0.83（95% CI：0.74-0.92），T2DM 的 RR 为 0.96（95% CI：0.95-0.98）。此外，木质素摄入与 CVD（非线性 < 0.001）和 T2DM（非线性 < 0.001）之间均呈曲线剂量-反应关系。这些结果表明，较高的木质素摄入可能与 CVD 和 T2DM 的风险降低呈剂量依赖性相关。