非编码 RNA 回路在黑色素瘤发生、可塑性和治疗反应中的作用。
Noncoding RNA circuitry in melanoma onset, plasticity, and therapeutic response.
机构信息
Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA; Department of Dermatology, School of Medicine, University of Patras, 26504 Patras, Greece.
Cancer Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
出版信息
Pharmacol Ther. 2023 Aug;248:108466. doi: 10.1016/j.pharmthera.2023.108466. Epub 2023 Jun 8.
Melanoma, the cancer of the melanocyte, is the deadliest form of skin cancer with an aggressive nature, propensity to metastasize and tendency to resist therapeutic intervention. Studies have identified that the re-emergence of developmental pathways in melanoma contributes to melanoma onset, plasticity, and therapeutic response. Notably, it is well known that noncoding RNAs play a critical role in the development and stress response of tissues. In this review, we focus on the noncoding RNAs, including microRNAs, long non-coding RNAs, circular RNAs, and other small RNAs, for their functions in developmental mechanisms and plasticity, which drive onset, progression, therapeutic response and resistance in melanoma. Going forward, elucidation of noncoding RNA-mediated mechanisms may provide insights that accelerate development of novel melanoma therapies.
黑色素瘤是黑素细胞的癌症，是最致命的皮肤癌形式，具有侵袭性、易转移和抵抗治疗干预的倾向。研究已经确定，黑色素瘤中发育途径的重新出现有助于黑色素瘤的发生、可塑性和治疗反应。值得注意的是，非编码 RNA 在组织的发育和应激反应中起着关键作用，这是众所周知的。在这篇综述中，我们重点关注非编码 RNA，包括 microRNAs、长非编码 RNA、环状 RNA 和其他小 RNA，它们在发育机制和可塑性中的功能，这些功能驱动黑色素瘤的发生、进展、治疗反应和耐药性。展望未来，阐明非编码 RNA 介导的机制可能提供加速开发新型黑色素瘤疗法的见解。
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