miR-1294 在癌症中的肿瘤抑制作用和 ceRNA 网络。
The tumor suppressor role and ceRNA network of miR-1294 in cancer.
机构信息
Department of Clinical Medicine, School of Medicine, Zhejiang University City College, Hangzhou, 310000, China.
Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, 310016, China.
出版信息
Oncol Res. 2023 Mar 1;31(1):1-12. doi: 10.32604/or.2022.027359. eCollection 2023.
miRNAs are endogenous small RNAs that are important regulators of gene expression. miR-1294 was found to be significantly down-regulated in 15 cancers and regulated by 21 upstream regulators. miR-1294 affects the proliferation, migration, invasion, and apoptosis of cancer cells. The target genes of miR-1294 are involved in the PI3K/AKT/mTOR, RAS, and JAK/STAT signaling pathways. Six target genes of miR-1294 are the targets of a variety of drugs. Low expression of miR-1294 is associated with resistance to cisplatin and TMZ and a poorer prognosis in patients with ESCC, GC, EOC, PDAC, or NSCLC. Therefore, this work outlines the molecular mechanisms and provides a basis for the clinical significance of the tumor suppressor miR-1294 in cancer.
miRNAs 是内源性的小 RNA，是基因表达的重要调节因子。研究发现 miR-1294 在 15 种癌症中显著下调，并受 21 个上游调节因子调节。miR-1294 影响癌细胞的增殖、迁移、侵袭和凋亡。miR-1294 的靶基因参与 PI3K/AKT/mTOR、RAS 和 JAK/STAT 信号通路。miR-1294 的六个靶基因是多种药物的靶点。miR-1294 表达水平低与 ESCC、GC、EOC、PDAC 或 NSCLC 患者对顺铂和 TMZ 的耐药性以及预后不良有关。因此，这项工作概述了肿瘤抑制因子 miR-1294 在癌症中的分子机制，并为其临床意义提供了依据。
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