三棘孢菌素 A-D，XM-3 木霉产生的四个新的聚酮化合物。
Trichodermatides A-D, four new polyketides from Trichoderma sp. XM-3.
机构信息
Editoral Department of Journals, Guangdong Pharmaceutical University, Guangzhou 510006, People's Republic of China; Center for New Drug Research and Development, Guangdong Pharmaceutical University, Guangzhou 510006, People's Republic of China; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People's Republic of China.
Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People's Republic of China.
出版信息
Fitoterapia. 2023 Sep;169:105584. doi: 10.1016/j.fitote.2023.105584. Epub 2023 Jun 15.
Four new polyketides named trichodermatides A-D (1-4), along with five known analogues (5-9), were isolated from the fungus Trichoderma sp. XM-3. Their structures were elucidated on the basis of HRESIMS and NMR analyses, and their absolute configurations were determined by ECD comparison, H and C NMR calculation, DP4+ analysis, modified Mosher's method, and X-ray crystallography. Trichodermaketone D (9) showed mild antibacterial activity against Pseudomonas aeruginosa.
从真菌 Trichoderma sp. XM-3 中分离得到了四个新的聚酮化合物，分别命名为 trichodermatides A-D（1-4），以及五个已知类似物（5-9）。基于高分辨质谱（HRESIMS）和核磁共振（NMR）分析，确定了它们的结构，并通过 ECD 比较、1H 和 13C NMR 计算、DP4+分析、改进的 Mosher 法和 X 射线晶体学确定了它们的绝对构型。trichodermaketone D（9）对铜绿假单胞菌表现出轻微的抗菌活性。
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