病例报告：通过血液检测启动的PET-CT成像在无症状个体中早期检测肺类癌。

Case Report: Early detection of lung carcinoid in an asymptomatic individual by blood-test initiated PET-CT imaging.

作者信息

Burg Simon, Smeets Ralf, Gosau Martin, Failing Katja, Grust Audrey Laure Céline

机构信息

Department of Oral and Maxillofacial Surgery, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.

Department of Oral and Maxillofacial Surgery, Division of "Regenerative Orofacial Medicine", University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.

出版信息

Front Oncol. 2023 Jun 6;13:1177237. doi: 10.3389/fonc.2023.1177237. eCollection 2023.

DOI:10.3389/fonc.2023.1177237

PMID:37346076

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10280377/

Abstract

We present the case of a 53-year-old woman who was diagnosed with early-stage lung cancer by targeted cancer screening consisting of an immunological biopsy-based blood test followed by radiological imaging. The PanTum Detect blood test detects the biomarkers Apo10/DNaseX and Transketolase-like 1 (TKTL1) in circulating macrophage-like cells from peripheral blood samples to identify asymptomatic individuals with a high risk for malignancy. The elevated blood test values initiated an F-FDG PET/CT visualization for further clarification. In this case, imaging indicated a lung carcinoma in the right upper lobe. A biopsy confirmed the presence of a lung carcinoma, which was removed surgically. Histologic examination revealed a typical I A2 carcinoid, which was completely removed, making further therapy obsolete.

摘要

我们报告了一例53岁女性病例，该患者通过靶向癌症筛查被诊断为早期肺癌，筛查包括基于免疫活检的血液检测及后续的放射影像学检查。PanTum Detect血液检测可检测外周血样本中循环巨噬细胞样细胞中的生物标志物Apo10/DNaseX和转酮醇酶样1（TKTL1），以识别恶性肿瘤高风险的无症状个体。血液检测值升高促使进行F-FDG PET/CT显像以进一步明确情况。在此病例中，影像学显示右上叶有肺癌。活检证实存在肺癌，随后进行了手术切除。组织学检查显示为典型的I A2类癌，已完全切除，无需进一步治疗。