成年孕前糖尿病妇女新生儿出生体重的预测因素：一项回顾性观察研究。

Predictive factors of weight at birth of newborns of adult women with pregestational Diabetes Mellitus : A retrospective observational study.

机构信息

Programa de Residência Multiprofissional em Saúde Perinatal, Maternidade Escola, Universidade Federal do Rio de Janeiro (UFRJ), Rua das Laranjeiras, 180, Laranjeiras, CEP 22240-003 Rio de Janeiro, RJ, Brazil.

Maternidade Escola, Universidade Federal do Rio de Janeiro (UFRJ), Rua das Laranjeiras, 180, Laranjeiras, CEP 22240-003 Rio de Janeiro, RJ, Brazil.

出版信息

Diabetes Res Clin Pract. 2023 Aug;202:110797. doi: 10.1016/j.diabres.2023.110797. Epub 2023 Jun 21.

DOI:10.1016/j.diabres.2023.110797

PMID:37352936

Abstract

AIMS

To identify predictive factors of birth weight (BW) of newborns of women with pregestational diabetes mellitus (DM).

METHODS

Retrospective observational study with data from pregnant women who started prenatal nutritional monitoring up to 28 weeks, single pregnancy, and BW information. Quantitative variables were analyzed, and mean and standard deviation (SD) measures or medians and interquartile ranges (IQR) were calculated. Predictive factors were identified using multivariate linear regression.

RESULTS

Eighty-six pregnant women were analyzed, 50% were diagnosed with type 1 DM, 46.5% with type 2 DM, and 3.5% with unclassified DM; 41% were mixed black and white, 35.6% had overweight and 33.3% had pregestational obesity. The mean BW was 3313.93 g (SD = 696.08). The predictive factors identified were: gestational weight gain (GWG) at the 3rd trimester (ß=60.42; p = 0.04), and gestational age at delivery (ß=194.03; p < 0.001); adjusted by time of diagnosis of DM (p = 0.07) and 1st-trimester glycated hemoglobin (p = 0.71).

CONCLUSION

The best predictors of BW were gestational age at birth and maternal anthropometric gestational characteristics, which are modifiable variables. The results may contribute to a review of the prenatal routines of pregnant women with DM.

摘要

目的

确定孕前糖尿病（DM）女性新生儿出生体重（BW）的预测因素。

方法

这是一项回顾性观察性研究，数据来自于接受产前营养监测至 28 周的孕妇，单胎妊娠，且有 BW 信息。分析了定量变量，并计算了均值和标准差（SD）或中位数和四分位距（IQR）。使用多元线性回归确定预测因素。

结果

分析了 86 名孕妇，50%诊断为 1 型 DM，46.5%诊断为 2 型 DM，3.5%为未分类 DM；41%为混合黑白人种，35.6%超重，33.3%孕前肥胖。BW 的平均值为 3313.93g（SD=696.08）。确定的预测因素有：第 3 孕期的体重增长（GWG）（β=60.42；p=0.04）和分娩时的孕龄（β=194.03；p<0.001）；调整 DM 诊断时间（p=0.07）和 1 孕期糖化血红蛋白（p=0.71）。