探索伴侣动物中病毒与癌症之间的联系：一项全面的比较分析。

Exploring the link between viruses and cancer in companion animals: a comprehensive and comparative analysis.

作者信息

Parisi Francesca, Fonti Niccolò, Millanta Francesca, Freer Giulia, Pistello Mauro, Poli Alessandro

机构信息

Dipartimento di Scienze Veterinarie, Università di Pisa, Viale delle Piagge, 2, 56124, Pisa, Italy.

Dipartimento di Ricerca Traslazionale e delle Nuove Tecnologie in Medicina e Chirurgia, Università di Pisa, Via Risorgimento, 36, 56126, Pisa, Italy.

出版信息

Infect Agent Cancer. 2023 Jun 29;18(1):40. doi: 10.1186/s13027-023-00518-7.

DOI:10.1186/s13027-023-00518-7

PMID:37386451

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10308683/

Abstract

Currently, it is estimated that 15% of human neoplasms globally are caused by infectious agents, with new evidence emerging continuously. Multiple agents have been implicated in various forms of neoplasia, with viruses as the most frequent. In recent years, investigation on viral mechanisms underlying tumoral transformation in cancer development and progression are in the spotlight, both in human and veterinary oncology. Oncogenic viruses in veterinary medicine are of primary importance not only as original pathogens of pets, but also in the view of pets as models of human malignancies. Hence, this work will provide an overview of the main oncogenic viruses of companion animals, with brief notes of comparative medicine.

摘要

目前，据估计全球15%的人类肿瘤是由感染因子引起的，且新证据不断涌现。多种因子与各种形式的肿瘤形成有关，其中病毒最为常见。近年来，无论是在人类肿瘤学还是兽医学肿瘤学领域，关于癌症发生和发展过程中肿瘤转化的病毒机制的研究都备受关注。兽医学中的致癌病毒不仅作为宠物的原始病原体至关重要，而且从宠物作为人类恶性肿瘤模型的角度来看也很重要。因此，这项工作将概述伴侣动物的主要致癌病毒，并简要介绍比较医学。