原卟啉 IX 诱导的光毒性：机制与治疗。
Protoporphyrin IX-induced phototoxicity: Mechanisms and therapeutics.
机构信息
Center for Pharmacogenetics, Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Porphyria Laboratory and Center, Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX 77555, USA.
出版信息
Pharmacol Ther. 2023 Aug;248:108487. doi: 10.1016/j.pharmthera.2023.108487. Epub 2023 Jun 29.
Protoporphyrin IX (PPIX) is an intermediate in the heme biosynthesis pathway. Abnormal accumulation of PPIX due to certain pathological conditions such as erythropoietic protoporphyria and X-linked protoporphyria causes painful phototoxic reactions of the skin, which can significantly impact daily life. Endothelial cells in the skin have been proposed as the primary target for PPIX-induced phototoxicity through light-triggered generation of reactive oxygen species. Current approaches for the management of PPIX-induced phototoxicity include opaque clothing, sunscreens, phototherapy, blood therapy, antioxidants, bone marrow transplantation, and drugs that increase skin pigmentation. In this review, we discuss the present understanding of PPIX-induced phototoxicity including PPIX production and disposition, conditions that lead to PPIX accumulation, symptoms and individual differences, mechanisms, and therapeutics.
原卟啉 IX（PPIX）是血红素生物合成途径中的中间产物。由于某些病理情况，如红细胞生成性原卟啉症和 X 连锁原卟啉症，导致 PPIX 的异常积累，从而引起皮肤疼痛性光毒性反应，这会显著影响日常生活。皮肤中的内皮细胞已被提出为 PPIX 诱导的光毒性的主要靶标，通过光触发产生活性氧。目前管理 PPIX 诱导的光毒性的方法包括不透明衣物、防晒霜、光疗、血液疗法、抗氧化剂、骨髓移植和增加皮肤色素沉着的药物。在这篇综述中，我们讨论了目前对 PPIX 诱导的光毒性的理解，包括 PPIX 的产生和分布、导致 PPIX 积累的情况、症状和个体差异、机制和治疗方法。
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