通过芳基炔中间体和环己炔中间体合成亚磺酰亚胺。
Synthesis of Sulfilimines via Aryne and Cyclohexyne Intermediates.
机构信息
School of Pharmaceutical and Chemical Engineering & Institute for Advanced Studies, Taizhou University, Jiaojiang 318000, Zhejiang, China.
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China.
出版信息
Org Lett. 2023 Jul 14;25(27):5157-5161. doi: 10.1021/acs.orglett.3c01918. Epub 2023 Jul 5.
An efficient and metal-free approach for the synthesis of sulfilimines from sulfenamides with aryne and cyclohexyne precursors has been developed. The reaction proceeds through unusual S-C bond formation, which offers a novel and practical entry to access a wide range of sulfilimines in moderate to good yields with excellent chemoselectivity. Moreover, this protocol is amenable to gram-scale synthesis and is applicable to the transformation of the products into useful sulfoximines.
一种高效、无金属的方法，用于通过芳基炔和环己炔前体，从亚磺酰胺合成亚磺酰亚胺。该反应通过不寻常的 S-C 键形成进行，为广泛获得各种亚磺酰亚胺提供了新颖而实用的途径，产率中等至良好，具有优异的化学选择性。此外，该方案适用于克级合成，并且可用于将产物转化为有用的亚砜亚胺。
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