Rathee Priyanka, Sehrawat Renu, Rathee Pooja, Khatkar Anurag, Akkol Esra Küpeli, Khatkar Sarita, Redhu Neelam, Türkcanoğlu Gizem, Sobarzo-Sánchez Eduardo
Faculty of Pharmaceutical Sciences, Baba Mastnath University, Rohtak 124021, India.
School of Medical and Allied Sciences, K.R. Mangalam University, Gurugram 122103, India.
Materials (Basel). 2023 Jul 3;16(13):4793. doi: 10.3390/ma16134793.
The global market of food, cosmetics, and pharmaceutical products requires continuous tracking of harmful ingredients and microbial contamination for the sake of the safety of both products and consumers as these products greatly dominate the consumer's health, directly or indirectly. The existence, survival, and growth of microorganisms in the product may lead to physicochemical degradation or spoilage and may infect the consumer at another end. It has become a challenge for industries to produce a product that is safe, self-stable, and has high nutritional value, as many factors such as physical, chemical, enzymatic, or microbial activities are responsible for causing spoilage to the product within the due course of time. Thus, preservatives are added to retain the virtue of the product to ensure its safety for the consumer. Nowadays, the use of synthetic/artificial preservatives has become common and has not been widely accepted by consumers as they are aware of the fact that exposure to preservatives can lead to adverse effects on health, which is a major area of concern for researchers. Naturally occurring phenolic compounds appear to be extensively used as bio-preservatives to prolong the shelf life of the finished product. Based on the convincing shreds of evidence reported in the literature, it is suggested that phenolic compounds and their derivatives have massive potential to be investigated for the development of new moieties and are proven to be promising drug molecules. The objective of this article is to provide an overview of the significant role of phenolic compounds and their derivatives in the preservation of perishable products from microbial attack due to their exclusive antioxidant and free radical scavenging properties and the problems associated with the use of synthetic preservatives in pharmaceutical products. This article also analyzes the recent trends in preservation along with technical norms that regulate the food, cosmetic, and pharmaceutical products in the developing countries.
食品、化妆品和药品的全球市场需要持续追踪有害成分和微生物污染情况,以确保产品和消费者的安全,因为这些产品对消费者的健康有着直接或间接的重大影响。产品中微生物的存在、存活和生长可能导致物理化学降解或变质,并可能在另一端感染消费者。对各行业来说,生产出安全、自稳定且具有高营养价值的产品已成为一项挑战,因为物理、化学、酶促或微生物活动等许多因素都会在适当的时候导致产品变质。因此,会添加防腐剂来保持产品的品质,以确保其对消费者的安全性。如今,合成/人工防腐剂的使用已很普遍,但并未被消费者广泛接受,因为他们知道接触防腐剂会对健康产生不良影响,这是研究人员主要关注的领域。天然存在的酚类化合物似乎被广泛用作生物防腐剂,以延长成品的保质期。基于文献中报道的令人信服的证据,有人认为酚类化合物及其衍生物在开发新化合物方面有巨大的研究潜力,并且已被证明是有前景的药物分子。本文的目的是概述酚类化合物及其衍生物因其独特的抗氧化和自由基清除特性,在保护易腐产品免受微生物侵害方面所起的重要作用,以及在药品中使用合成防腐剂所带来的问题。本文还分析了发展中国家在食品、化妆品和药品保存方面的最新趋势以及相关技术规范。