Division of Intramural Research, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Md.
Uniformed Services University of the Health Science, Bethesda, Md; Henry M. Jackson Foundation for the Advancement of Military Medicine Inc, Bethesda, Md.
Am J Med. 2023 Nov;136(11):1079-1086.e1. doi: 10.1016/j.amjmed.2023.07.007. Epub 2023 Jul 21.
Morbidity and mortality related to heart failure are increasing and disparities are widening. These alarming trends, often confounded by access to care, are poorly understood. This study evaluates the prevalence of all stages of heart failure by race and socioeconomic status in an environment with no access barrier to care.
We conducted a cross-sectional observational study of adult beneficiaries aged 18 to 64 years of the Military Health System (MHS), a model for universal health care for fiscal years 2018-2019. We calculated prevalence of preclinical (stages A/B) or clinical (stages C/D) heart failure stages as defined by professional guidelines. Results were analyzed by age, race, and socioeconomic status (using military rank as a proxy).
Among 5,440,761 MHS beneficiaries aged 18 to 64 years, prevalence of preclinical and clinical heart failure was 18.1% and 2.5%, respectively. Persons with preclinical heart failure were middle aged, with similar proportions of men and women, while those with heart failure were older, mainly men. After multivariable adjustment, male sex (1.35 odds ratio [OR] [preclinical]; 1.95 OR [clinical]), Black race (1.64 OR [preclinical]; 1.88 OR [clinical]) and lower socioeconomic status were significantly associated with large increases in the prevalence of all stages of heart failure.
All stages of heart failure are highly prevalent among MHS beneficiaries of working age and, in an environment with no access barrier to care, there are striking disparities by race and socioeconomic status. The high prevalence of preclinical heart failure, particularly notable among Black beneficiaries, delineates a critical time window for prevention.
与心力衰竭相关的发病率和死亡率正在上升,且差距正在扩大。这些令人震惊的趋势,往往因获得医疗服务的机会而变得复杂,目前还没有得到很好的理解。本研究评估了在无医疗服务获取障碍的环境中,按种族和社会经济地位划分的所有心力衰竭阶段的患病率。
我们对 2018-2019 财年军事卫生系统(MHS)的 18 至 64 岁成年受益人的横断面观察性研究进行了评估。我们按照专业指南计算了临床前(A/B 期)或临床(C/D 期)心力衰竭阶段的患病率。结果按年龄、种族和社会经济地位(使用军衔作为替代指标)进行分析。
在 5440761 名 18 至 64 岁的 MHS 受益人中,临床前和临床心力衰竭的患病率分别为 18.1%和 2.5%。有临床前心力衰竭的患者年龄居中,男女比例相似,而有心力衰竭的患者年龄较大,主要是男性。经过多变量调整后,男性(临床前:1.35 优势比[OR];临床:1.95 OR)、黑种人(临床前:1.64 OR;临床:1.88 OR)和较低的社会经济地位与所有心力衰竭阶段患病率的大幅增加显著相关。
在 MHS 有工作能力的受益人群中,所有心力衰竭阶段的患病率都很高,且在无医疗服务获取障碍的环境中,按种族和社会经济地位划分的差异非常显著。临床前心力衰竭的高患病率,尤其是在黑人受益人群中,突显了一个预防的关键时间窗口。