ARID3a 来自 ARID 家族：结构、在自身免疫性疾病中的作用和药物发现。
ARID3a from the ARID family: structure, role in autoimmune diseases and drug discovery.
机构信息
Department of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease, Shanghai, 200001, China.
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
出版信息
Acta Pharmacol Sin. 2023 Nov;44(11):2139-2150. doi: 10.1038/s41401-023-01134-2. Epub 2023 Jul 24.
The AT-rich interaction domain (ARID) family of DNA-binding proteins is a group of transcription factors and chromatin regulators with a highly conserved ARID domain that recognizes specific AT-rich DNA sequences. Dysfunction of ARID family members has been implicated in various human diseases including cancers and intellectual disability. Among them, ARID3a has gained increasing attention due to its potential involvement in autoimmunity. In this article we provide an overview of the ARID family, focusing on the structure and biological functions of ARID3a. It explores the role of ARID3a in autoreactive B cells and its contribution to autoimmune diseases such as systemic lupus erythematosus and primary biliary cholangitis. Furthermore, we also discuss the potential for drug discovery targeting ARID3a and present a plan for future research in this field.
富含 AT 的相互作用结构域 (ARID) 家族的 DNA 结合蛋白是一组转录因子和染色质调节剂，具有高度保守的 ARID 结构域，可识别特定的富含 AT 的 DNA 序列。ARID 家族成员的功能障碍与多种人类疾病有关，包括癌症和智力障碍。其中，ARID3a 由于其潜在的自身免疫参与而受到越来越多的关注。本文概述了 ARID 家族，重点介绍了 ARID3a 的结构和生物学功能。它探讨了 ARID3a 在自身反应性 B 细胞中的作用及其对系统性红斑狼疮和原发性胆汁性胆管炎等自身免疫性疾病的贡献。此外，我们还讨论了针对 ARID3a 的药物发现的潜力，并提出了该领域未来研究的计划。
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