Department of Organization and Management and Economics of Pharmacy and Clinical Pharmacy, Asfendiyarov Kazakh National Medical University, 94 Tole Bi Str., 050000, Almaty, Republic of Kazakhstan.
Department of Organization and Management of Pharmaceutical Business, South Kazakhstan Medical Academy, 160019, 1 Al-Farabi Sq., Shymkent, Republic of Kazakhstan.
Naunyn Schmiedebergs Arch Pharmacol. 2024 Feb;397(2):807-815. doi: 10.1007/s00210-023-02634-y. Epub 2023 Jul 26.
Medicinal preparations made from plant materials have been widely used for many years due to their high pharmacological efficacy and safety of use. Therefore, a study of white mulberry fruits (Morus alba L.) for the content of substances is very important for the pharmaceutical industry such as flavonoids, alkaloids, polysaccharides, minerals, vitamins, and amino acids. White mulberry has a wide distribution area around the world, including in Kazakhstan, especially in the southern regions of the country (Almaty, Zhambyl, and Turkestan regions). The composition of the fruits of this plant is significantly influenced by the area where the trees grow, and therefore, the establishment of a specific composition of biologically active substances is very important. In the course of this study, such methods as gas chromatography were used-mass spectrometry of an extract obtained using carbon dioxide under subcritical conditions, atomic absorption, gravimetric, and spectrophotometric methods. As a result, for the first time in Kazakhstan, the composition of white mulberry fruits (Morus alba L.), namely, biologically active substances, has been identified, such as alkaloids, flavonoids, vitamins, macro- and microelements, and amino acids and fatty acids; in addition, the percentage composition of the above compounds has been determined. The results of the study show a comparative analysis of the component composition of white mulberry fruits (Morus alba L.) in various areas of tree growth, including outside of Kazakhstan. The obtained data testify to the great possibilities of using this raw material in medicine, pharmacology, and the food industry.
由于植物药材具有较高的药理功效和使用安全性,因此多年来一直被广泛应用。因此,对白色桑椹果实(Morus alba L.)中黄酮类、生物碱类、多糖类、矿物质、维生素和氨基酸等物质的含量进行研究,对制药等行业非常重要。白色桑椹在世界各地分布广泛,包括哈萨克斯坦,尤其是在该国南部地区(阿拉木图、江布尔和突厥斯坦地区)。该植物果实的成分受树木生长地区的显著影响,因此,建立特定的生物活性物质组成非常重要。在这项研究中,使用了诸如气相色谱-质谱法等方法,使用二氧化碳在亚临界条件下提取,并采用原子吸收、重量分析和分光光度法。结果,首次在哈萨克斯坦确定了白色桑椹果实(Morus alba L.)的生物活性物质成分,如生物碱、黄酮类、维生素、宏量和微量元素以及氨基酸和脂肪酸;此外,还确定了上述化合物的百分比组成。研究结果显示了对包括哈萨克斯坦以外地区的不同生长地区的白色桑椹果实(Morus alba L.)的成分组成进行了比较分析。所得数据证明了该原料在医学、药理学和食品工业中具有巨大的应用潜力。