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药物滥用和基因兴奋剂检测分析的最新进展综述。

A Review of Recent Progress in Drug Doping and Gene Doping Control Analysis.

机构信息

Laboratory of Biochemistry, School of Physical Education, China University of Geosciences, Wuhan 430074, China.

Key Laboratory of Novel Materials for Sensor of Zhejiang Province, College of Materials and Environmental Engineering, Hangzhou Dianzi University, Hangzhou 310018, China.

出版信息

Molecules. 2023 Jul 18;28(14):5483. doi: 10.3390/molecules28145483.

Abstract

The illicit utilization of performance-enhancing substances, commonly referred to as doping, not only infringes upon the principles of fair competition within athletic pursuits but also poses significant health hazards to athletes. Doping control analysis has emerged as a conventional approach to ensuring equity and integrity in sports. Over the past few decades, extensive advancements have been made in doping control analysis methods, catering to the escalating need for qualitative and quantitative analysis of numerous banned substances exhibiting diverse chemical and biological characteristics. Progress in science, technology, and instrumentation has facilitated the proliferation of varied techniques for detecting doping. In this comprehensive review, we present a succinct overview of recent research developments within the last ten years pertaining to these doping detection methodologies. We undertake a comparative analysis, evaluating the merits and limitations of each technique, and offer insights into the prospective future advancements in doping detection methods. It is noteworthy that the continual design and synthesis of novel synthetic doping agents have compelled researchers to constantly refine and innovate doping detection methods in order to address the ever-expanding range of covertly employed doping agents. Overall, we remain in a passive position for doping detection and are always on the road to doping control.

摘要

禁用物质的非法使用,通常被称为兴奋剂,不仅违反了体育竞赛的公平竞争原则,还对运动员的健康造成了重大危害。兴奋剂检测分析已成为确保体育比赛公平公正的常规手段。在过去几十年中,兴奋剂检测分析方法取得了广泛的进展,以满足对具有不同化学和生物学特性的大量禁用物质进行定性和定量分析的需求。科学、技术和仪器的进步促进了各种检测兴奋剂的技术的发展。在本综述中,我们简要概述了过去十年中与这些兴奋剂检测方法相关的最新研究进展。我们进行了比较分析,评估了每种技术的优缺点,并探讨了兴奋剂检测方法的未来发展前景。值得注意的是,新型合成兴奋剂的不断设计和合成迫使研究人员不断改进和创新兴奋剂检测方法,以应对不断扩大的隐蔽使用兴奋剂范围。总的来说,我们在兴奋剂检测方面处于被动地位,始终致力于兴奋剂控制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64bf/10386588/c52d95282234/molecules-28-05483-g001.jpg

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