使用非水溶剂阳离子交换色谱法和萃取色谱法从铁靶中分离回旋加速器产生的钴-55/58m。
Separation of cyclotron-produced cobalt-55/58m from iron targets using cation exchange chromatography with non-aqueous solvents and extraction chromatography.
作者信息
Lin Wilson, Aluicio-Sarduy Eduardo, Barrett Kendall E, Barnhart Todd E, Mixdorf Jason C, DeLuca Molly C, Engle Jonathan W
机构信息
Department of Medical Physics, University of Wisconsin, 1111 Highland Ave., Madison, WI, 53705, United States.
Department of Medical Physics, University of Wisconsin, 1111 Highland Ave., Madison, WI, 53705, United States.
出版信息
Appl Radiat Isot. 2023 Oct;200:110980. doi: 10.1016/j.apradiso.2023.110980. Epub 2023 Aug 12.
Cobalt-55 and -58m form a theranostic pair that has relevant properties for cancer research. We report a cation exchange chromatography/extraction chromatography method that separates cyclotron-produced Co from Fe in <1.5 h, recovers >85% Co and achieves [Co]Co-NOTA and -DOTA AMA 89 ± 48 and 35 ± 7 MBq/nmol (EOB), respectively. Cobalt-55 and -58m were quantitatively labeled to functionalized NOTA at 106 and 50 MBq/nmol (EOB), respectively, corroborating measured AMA. This method is faster than previously published methods and achieves better [Co]Co-NOTA and -DOTA AMA.
钴-55和-58m构成了一对具有癌症研究相关特性的诊疗组合。我们报道了一种阳离子交换色谱/萃取色谱方法，该方法能在不到1.5小时内将回旋加速器产生的钴与铁分离，钴回收率>85%，并分别实现[钴]钴- NOTA和- DOTA AMA为89±48和35±7 MBq/ nmol（给药结束时）。钴-55和-58m分别以106和50 MBq/ nmol（给药结束时）的量定量标记到功能化的NOTA上，证实了测量的AMA。该方法比先前发表的方法更快，并且实现了更好的[钴]钴- NOTA和- DOTA AMA。
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