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德国 1 型糖尿病患者中,与糖尿病技术使用相关的地区贫困和人口统计学因素。

Area deprivation and demographic factors associated with diabetes technology use in adults with type 1 diabetes in Germany.

机构信息

Institute of Epidemiology and Medical Biometry, Ulm University, Ulm, Germany.

German Center for Diabetes Research (DZD), Munich-Neuherberg, Germany.

出版信息

Front Endocrinol (Lausanne). 2023 Aug 1;14:1191138. doi: 10.3389/fendo.2023.1191138. eCollection 2023.

Abstract

INTRODUCTION

Diabetes technology improves glycemic control and quality of life for many people with type 1 diabetes (T1D). However, inequalities in access to diabetes technology exist in many countries. In Germany, disparities in technology use have been described in pediatric T1D, but no data for adults are available so far. We therefore aimed to analyze whether demographic factors and area deprivation are associated with technology use in a representative population of adults with T1D.

MATERIALS AND METHODS

In adults with T1D from the German prospective diabetes follow-up registry (DPV), we analyzed the use of continuous subcutaneous insulin infusion (CSII), continuous glucose monitoring (CGM), and sensor augmented pump therapy (SAP, with and without automated insulin delivery) in 2019-2021 by age group, gender, migration background, and area deprivation using multiple adjusted regression models. Area deprivation, defined as a relative lack of area-based resources, was measured by quintiles of the German index of Multiple Deprivation (GIMD 2015, from Q1, least deprived, to Q5, most deprived districts).

RESULTS

Among 13,351 adults with T1D, the use of technology decreased significantly with older age: CSII use fell from 56.1% in the 18-<25-year age group to 3.1% in the ≥80-year age group, CGM use from 75.3% to 28.2%, and SAP use from 45.1% to 1.5% (all p for trend <0.001). The use of technology was also significantly higher in women than in men (CSII: 39.2% vs. 27.6%; CGM: 61.9% vs. 58.0%; SAP: 28.7% vs. 19.6%, all p <0.001), and in individuals without migration background than in those with migration background (CSII: 38.8% vs. 27.6%; CGM: 71.1% vs. 61.4%; SAP: 30.5% vs. 21.3%, all p <0.001). Associations with area deprivation were not linear: the use of each technology decreased only from Q2 to Q4.

DISCUSSION

Our real-world data provide evidence that higher age, male gender, and migration background are currently associated with lower use of diabetes technology in adults with T1D in Germany. Associations with area deprivation are more complex, probably due to correlations with other factors, like the higher proportion of migrants in less deprived areas or the federal structure of the German health care system.

摘要

简介

糖尿病技术改善了许多 1 型糖尿病(T1D)患者的血糖控制和生活质量。然而,许多国家在获得糖尿病技术方面存在不平等现象。在德国,儿科 T1D 中已经描述了技术使用方面的差异,但目前尚无成人的数据。因此,我们旨在分析在德国前瞻性糖尿病随访登记处(DPV)的代表性成人 T1D 人群中,人口统计学因素和地区贫困程度与技术使用是否相关。

方法

我们分析了 2019-2021 年德国前瞻性糖尿病随访登记处(DPV)中成人 T1D 患者按年龄组、性别、移民背景和地区贫困程度使用连续皮下胰岛素输注(CSII)、连续血糖监测(CGM)和传感器增强型泵治疗(SAP,带或不带自动胰岛素输送)的情况。使用多因素调整回归模型,通过德国多重剥夺指数(GIMD 2015,从 Q1 最不贫困到 Q5 最贫困地区)的五分位数来衡量地区贫困程度,定义为相对缺乏基于地区的资源。

结果

在 13351 名成人 T1D 患者中,随着年龄的增长,技术的使用显著下降:CSII 的使用从 18-<25 岁年龄组的 56.1%下降到≥80 岁年龄组的 3.1%,CGM 的使用从 75.3%下降到 28.2%,SAP 的使用从 45.1%下降到 1.5%(所有趋势 p<0.001)。与男性相比,女性使用技术的比例也明显更高(CSII:39.2% vs. 27.6%;CGM:61.9% vs. 58.0%;SAP:28.7% vs. 19.6%,均 p<0.001),与无移民背景的个体相比,有移民背景的个体使用技术的比例也更高(CSII:38.8% vs. 27.6%;CGM:71.1% vs. 61.4%;SAP:30.5% vs. 21.3%,均 p<0.001)。与地区贫困的关联不是线性的:仅从 Q2 到 Q4,每种技术的使用才会下降。

讨论

我们的真实数据表明,在德国,年龄较大、男性和移民背景与成人 T1D 中糖尿病技术的使用较低有关。与地区贫困的关联更加复杂,可能是由于与其他因素(如较贫困地区移民比例较高或德国卫生保健系统的联邦结构)相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b22/10433185/a1e00abf7c43/fendo-14-1191138-g001.jpg

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