用于区分癌细胞和正常细胞以及诊断脂肪肝的脂滴特异性近红外荧光探针。
Lipid droplet-specific near-infrared fluorescent probe for discriminating cancer and normal cells and diagnosing fatty liver.
机构信息
College of Chemistry and Materials Science, Key Laboratory of Chemical Biology of Hebei Province, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis (Ministry of Education), Hebei University, Baoding 071002, PR China.
Department of Chemical Biology, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, PR China.
出版信息
Bioorg Chem. 2023 Nov;140:106800. doi: 10.1016/j.bioorg.2023.106800. Epub 2023 Aug 22.
Lipid droplets (LDs) is a newly essential organelle, which participates in carious physiological and pathological processes. LDs are considered as potential markers for disease diagnosis. Specific imaging of LDs is useful to understand their basic biological function and to diagnose diseases. Here we designed and synthesized two fluorescent probes based on the low polarity and high viscosity in LDs. The terminal probe ZH-2 exhibits lipophilicity, NIR emission, viscosity sensitivity, and LDs specificity. The probe has been successfully used for visualizing LDs metabolism, discriminating between normal and cancerous cells, and diagnosing fatty liver disease.
脂滴（LDs）是一种新的必需细胞器，参与多种生理和病理过程。LDs 被认为是疾病诊断的潜在标志物。对 LDs 的特异性成像有助于了解其基本生物学功能和诊断疾病。在这里，我们设计并合成了两种基于 LDs 低极性和高粘度的荧光探针。末端探针 ZH-2 具有亲脂性、近红外发射、粘度敏感性和 LDs 特异性。该探针已成功用于可视化 LDs 代谢、区分正常细胞和癌细胞以及诊断脂肪肝疾病。
Zotero 插件