染色质结合 RB 的图案。
Patterns in the tapestry of chromatin-bound RB.
机构信息
Massachusetts General Hospital Cancer Center and Harvard Medical School, Building 149, 13th Street, Charlestown, MA 02129, USA.
Massachusetts General Hospital Cancer Center and Harvard Medical School, Building 149, 13th Street, Charlestown, MA 02129, USA; Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA 02142, USA.
出版信息
Trends Cell Biol. 2024 Apr;34(4):288-298. doi: 10.1016/j.tcb.2023.07.012. Epub 2023 Aug 28.
The retinoblastoma protein (RB)-mediated regulation of E2F is a component of a highly conserved cell cycle machine. However, RB's tumor suppressor activity, like RB's requirement in animal development, is tissue-specific, context-specific, and sometimes appears uncoupled from cell proliferation. Detailed new information about RB's genomic distribution provides a new perspective on the complexity of RB function, suggesting that some of its functional specificity results from context-specific RB association with chromatin. Here we summarize recent evidence showing that RB targets different types of chromatin regulatory elements at different cell cycle stages. RB controls traditional RB/E2F targets prior to S-phase, but, when cells proliferate, RB redistributes to cell type-specific chromatin loci. We discuss the broad implications of the new data for RB research.
视网膜母细胞瘤蛋白（RB）介导的 E2F 调节是高度保守的细胞周期机器的一个组成部分。然而，RB 的肿瘤抑制活性，就像 RB 在动物发育中的要求一样，是组织特异性、上下文特异性的，有时似乎与细胞增殖脱钩。关于 RB 基因组分布的详细新信息为 RB 功能的复杂性提供了一个新的视角，表明其某些功能特异性是由 RB 与染色质的上下文特异性关联产生的。在这里，我们总结了最近的证据，表明 RB 在不同的细胞周期阶段靶向不同类型的染色质调节元件。RB 在 S 期前控制传统的 RB/E2F 靶标，但当细胞增殖时，RB 重新分布到细胞类型特异性染色质位点。我们讨论了新数据对 RB 研究的广泛影响。
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