Regmi Milan, Karki Anurag, Bhandari Sanjeev, Shrestha Moon, Kafle Pooja
Internal Medicine, Tribhuvan University Institute of Medicine, Kathmandu, NPL.
Critical Care Medicine, Tribhuvan University Institute of Medicine, Kathmandu, NPL.
Cureus. 2023 Jul 30;15(7):e42700. doi: 10.7759/cureus.42700. eCollection 2023 Jul.
Diabetic ketoacidosis (DKA) is a potentially fatal metabolic complication seen in individuals with type 1 diabetes mellitus (DM) or type 2 DM under stress, such as infections and non-compliance with treatment. DKA in chronic kidney disease (CKD) patients undergoing maintenance hemodialysis (HD) presents challenges due to the unique pathophysiology and the absence of specific management guidelines. This case report highlights the importance of tailoring the treatment of DKA based on the specific requirements of CKD patients on HD. The presented case involves a 47-year-old female with type 2 DM and CKD who developed DKA in the context of a urinary tract infection (UTI). Management included insulin infusion, cautious fluid replacement therapy, electrolyte monitoring, and identifying precipitating factors, such as an infection. The case highlights the complexity of DKA management in CKD patients and the necessity of individualized approaches. More studies and guidelines are needed to optimize the proper management of DKA in CKD patients.
糖尿病酮症酸中毒(DKA)是1型糖尿病(DM)患者或应激状态下的2型糖尿病患者(如感染和治疗依从性差)中可能发生的致命性代谢并发症。接受维持性血液透析(HD)的慢性肾脏病(CKD)患者发生DKA,因其独特的病理生理学和缺乏具体的管理指南而面临挑战。本病例报告强调了根据接受HD的CKD患者的具体需求调整DKA治疗的重要性。所呈现的病例是一名47岁患有2型糖尿病和CKD的女性,在尿路感染(UTI)的情况下发生了DKA。治疗措施包括胰岛素输注、谨慎的补液治疗、电解质监测以及识别诱发因素,如感染。该病例突出了CKD患者DKA管理的复杂性以及个体化方法的必要性。需要更多的研究和指南来优化CKD患者DKA的恰当管理。