马尔堡病毒病的死亡率、感染方式、诊断检测及治疗：一项系统综述
The mortality, modes of infection, diagnostic tests, and treatments of Marburg virus disease: A systematic review.
作者信息
Alla Deekshitha, Paruchuri Sai Sri Hari, Tiwari Angad, Alla Sai Santhosha Mrudula, Pillai Rakesh Thulaseedharan, Bandakadi Sandeep Kumar Reddy, Pradeep Anju, Shah Dhruv Jayeshkumar, Sabıroğlu Mert, Chavda Sachi, Biziyaremye Patrick
机构信息
Department of Medicine Andhra Medical College Visakhapatnam Andhra Pradesh India.
Dr. Pinnamaneni Siddhartha Institute of Medical Sciences and Research Foundation China Avutapalle Andhra Pradesh India.
出版信息
Health Sci Rep. 2023 Aug 31;6(9):e1545. doi: 10.1002/hsr2.1545. eCollection 2023 Sep.
BACKGROUND AND AIMS
Marburg virus (MARV) has regularly affected people since 1967 causing multiple outbreaks. There are presently no authorized therapies for the fatal Marburg virus disease (MVD), which poses an imminent risk to global public health. The MVD has so far claimed the lives of numerous people, with an increased number of cases being seen throughout the African continent. Hence, a review was carried out to analyze the geographical distribution of MVD, mortality, routes of transmission, and diagnostic and treatment modalities.
METHODS
PubMed, Scopus, Web of Science, Google Scholar, and ProMED servers were used to conduct a systematic search in compliance with the PRISMA guidelines. The results were tabulated and analyzed.
RESULTS
A total of 11 studies (7 case reports and 4 case series) were included in the final analysis, and 21 cases of MVD were analyzed. The most frequent symptoms were fever (66.67%), vomiting (57.14%), headache (52.38%), diarrhea (52.38%), and pain (47.62%). The most commonly used diagnostic test was RT-PCR (42.11%). Contact transmission (50%) and zoonotic transmission (37.5%) were the most prevalent routes of transmission. Antibiotics (61.5%) were the first line of treatment. The most common complications were hemorrhage (60%) and coagulopathies (33.3%). The mortality rate was 57.1%.
CONCLUSION
To avoid disastrous consequences, it is essential to reiterate the necessity of early diagnosis and treatment of MVD.
背景与目的
自1967年以来，马尔堡病毒（MARV）时常感染人类，引发多次疫情爆发。目前，尚无获批用于治疗致命性马尔堡病毒病（MVD）的疗法，该病对全球公共卫生构成紧迫威胁。迄今为止，MVD已导致众多人死亡，且在非洲大陆病例数呈上升趋势。因此，开展了一项综述以分析MVD的地理分布、死亡率、传播途径以及诊断和治疗方式。
方法
依据PRISMA指南，使用PubMed、Scopus、科学网、谷歌学术和ProMED服务器进行系统检索。将结果制成表格并进行分析。
结果
最终分析纳入了11项研究（7例病例报告和4例病例系列），共分析了21例MVD病例。最常见的症状为发热（66.67%）、呕吐（57.14%）、头痛（52.38%）、腹泻（52.38%）和疼痛（47.62%）。最常用的诊断检测方法是逆转录聚合酶链反应（RT-PCR，42.11%）。接触传播（50%）和人畜共患传播（37.5%）是最主要的传播途径。抗生素（61.5%）是一线治疗药物。最常见的并发症是出血（60%）和凝血病（33.3%）。死亡率为57.1%。
结论
为避免灾难性后果，重申早期诊断和治疗MVD的必要性至关重要。
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