阿尔茨海默病（AD）与癫痫的双向关系：一项孟德尔随机研究。
The bidirectional relationship between Alzheimer's disease (AD) and epilepsy: A Mendelian randomization study.
机构信息
Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
China National Clinical Research Center for Neurological Diseases, Beijing, China.
出版信息
Brain Behav. 2023 Nov;13(11):e3221. doi: 10.1002/brb3.3221. Epub 2023 Sep 4.
BACKGROUND
There is a complex, bidirectional relationship between Alzheimer's disease (AD) and epilepsy. However, the causality of this association is unclear, as confounders play a role in this association.
METHODS
We conducted a Mendelian randomization (MR) study to clarify the causal relationship and direction of epilepsy on AD risk. We used publicly available summary statistics to obtain all genetic datasets for the MR analyses. AD and AD-by-proxy and late-onset AD (LOAD) cohorts were included in our study. The epilepsy cohort comprised all epilepsy, generalized epilepsy, focal epilepsy, and its subtypes, as well as some epilepsy syndromes. Next, we conducted validation using another AD cohort.
RESULTS
Two correlations between AD and epilepsy using the inverse variance-weighted (IVW) method are as follows: LOAD and focal epilepsy (OR = 1.079, p = .013), focal epilepsy-documented hippocampal sclerosis (HS) and AD (OR = 1.152, p = .017). The causal relationship between epilepsy-documented HS and AD has been validated (OR = 3.994, p = .027).
CONCLUSIONS
Our MR study provides evidence for a causal relationship between focal epilepsy-documented HS and AD.
背景
阿尔茨海默病（AD）和癫痫之间存在复杂的双向关系。然而，这种关联的因果关系尚不清楚，因为混杂因素在这种关联中起作用。
方法
我们进行了孟德尔随机化（MR）研究，以阐明癫痫对 AD 风险的因果关系和方向。我们使用公开可用的汇总统计数据获得了所有用于 MR 分析的遗传数据集。AD 和 AD 代理和迟发性 AD（LOAD）队列都包含在我们的研究中。癫痫队列包括所有癫痫、全身性癫痫、局灶性癫痫及其亚型以及一些癫痫综合征。接下来，我们使用另一个 AD 队列进行了验证。
结果
使用逆方差加权（IVW）方法的 AD 和癫痫之间的两个相关性如下：LOAD 和局灶性癫痫（OR = 1.079，p =.013），局灶性癫痫记录的海马硬化（HS）和 AD（OR = 1.152，p =.017）。癫痫记录的 HS 和 AD 之间的因果关系已经得到验证（OR = 3.994，p =.027）。
结论
我们的 MR 研究为癫痫记录的 HS 和 AD 之间存在因果关系提供了证据。
Zotero 插件