毛蕊花糖苷、松果菊苷、苍术苷对大鼠高原疲劳的功效及可能机制。
Efficacy of verbascoside, echinacoside, crenatoside on altitude-induced fatigue in rats and possible mechanism.
机构信息
College of Pharmacy, Lanzhou University, Lanzhou 730030, China.
2 Department of Pharmacy, the 940th Hospital of Joint Logistic Support Force of Chinese of the People's Liberation Army, Lanzhou 730050, China.
出版信息
J Tradit Chin Med. 2023 Oct;43(5):934-943. doi: 10.19852/j.cnki.jtcm.20230630.001.
OBJECTIVE
To study the efficacy and mechanism of three phenylethanoid glycosides (PhGs) (verbascoside, echinacoside, and crenatoside) on altitude-induced fatigue in rats.
METHODS
Altitude-induced fatigue model rats were established in a large hypobaric chamber. Swimming time, energy storage substances, metabolic enzymes, and metabolites were used to evaluate the anti-fatigue activities and mechanism of three PhGs (verbascoside, echinacoside, and crenatoside) (150 mg/kg, intragastric administration) in the hypoxic environment.
RESULTS
The three PhGs, especially verbascoside, could prolong the swimming time of rats, ameliorate the edema and inflammatory infiltration of liver and skeletal muscle, increase the level of energy storage substances, reduce the decomposition of proteins, and exhibit positive effects on the metabolism-related enzyme activity and metabolites.
CONCLUSIONS
The PhGs, especially verbascoside, are very potential with anti-fatigue activity in hypoxia. The mechanism may be explained with regulation of energy metabolism and reduction of oxidative stress.
目的
研究三种苯乙醇苷（PhGs）（毛蕊花糖苷、麦角甾苷和獐牙菜苦苷）对高原疲劳大鼠的功效和作用机制。
方法
在大型低压舱中建立高原疲劳模型大鼠。通过游泳时间、储能物质、代谢酶和代谢物来评估三种 PhGs（毛蕊花糖苷、麦角甾苷和獐牙菜苦苷）（150mg/kg，灌胃）在低氧环境下的抗疲劳活性和作用机制。
结果
三种 PhGs，尤其是毛蕊花糖苷，可延长大鼠的游泳时间，改善肝脏和骨骼肌的水肿和炎症浸润，增加储能物质水平，减少蛋白质分解，并对代谢相关酶活性和代谢物产生积极影响。
结论
PhGs，尤其是毛蕊花糖苷，在低氧环境下具有很强的抗疲劳活性。其机制可能与调节能量代谢和降低氧化应激有关。
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