肥胖症的新疗法：对癌症预防和治疗的影响。
Novel Treatments for Obesity: Implications for Cancer Prevention and Treatment.
机构信息
Endocrine Unit, E.O. Ospedali Galliera, 16128 Genoa, Italy.
Division of Medical Oncology, E.O. Ospedali Galliera, 16128 Genoa, Italy.
出版信息
Nutrients. 2023 Aug 25;15(17):3737. doi: 10.3390/nu15173737.
It is now established that obesity is related to a higher incidence of cancer during a lifespan. The effective treatment of obesity opens up new perspectives in the treatment of a relevant modifiable cancer risk factor. The present narrative review summarizes the correlations between weight loss in obesity and cancer. The current knowledge between obesity treatment and cancer was explored, highlighting the greatest potential for its use in the treatment of cancer in the clinical setting. Evidence for the effects of obesity therapy on proliferation, apoptosis, and response to chemotherapy is summarized. While more studies, including large, long-term clinical trials, are needed to adequately evaluate the relationship and durability between anti-obesity treatment and cancer, collaboration between oncologists and obesity treatment experts is increasingly important.
现在已经确定，肥胖与一生中更高的癌症发病率有关。肥胖的有效治疗为治疗相关可改变的癌症风险因素开辟了新的前景。本叙述性综述总结了肥胖与癌症之间的体重减轻相关性。探讨了肥胖治疗与癌症之间的现有知识，突出了其在临床环境中治疗癌症的最大潜力。总结了肥胖症治疗对增殖、凋亡和对化疗反应的影响的证据。虽然需要更多的研究，包括大型、长期的临床试验，以充分评估抗肥胖治疗与癌症之间的关系和持久性，但肿瘤学家和肥胖治疗专家之间的合作变得越来越重要。
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