催乳素在帕金森病中可能发挥的作用：目标相同但方式各异。
The conceivable role of prolactin hormone in Parkinson disease: The same goal but with different ways.
作者信息
Al-Kuraishy Haydar M, Jabir Majid S, Al-Gareeb Ali I, Albuhadily Ali K
机构信息
Department of Clinical Pharmacology and Medicine, College of Medicine, Mustansiriyah University, Baghdad, Iraq.
Department of Applied Science, University of Technology, Iraq.
出版信息
Ageing Res Rev. 2023 Nov;91:102075. doi: 10.1016/j.arr.2023.102075. Epub 2023 Sep 14.
Parkinson disease (PD) is a progressive neurodegenerative disease (NDD) of the brain. It has been reported that prolactin (PRL) hormone plays a differential effect in PD, may be increasing, reduced or unaffected. PRL level is dysregulated in different neurodegenerative disorders including PD. Preclinical and clinical studies pointed out that PRL may has a neuroprotective against PD neuropathology . Though, the mechanistic role of PRL in PD is not fully elucidated. Therefore, the objective of the present review was to clarify the potential role and mechanistic pathway of PRL in PD neuropathology. The present review highlighted that PRL appears to have a neuroprotective effect against PD neuropathology by inhibiting the expression of pro-inflammatory signaling pathways, antioxidant effects and by inhibiting neuroinflammation. Thus, preclinical and clinical studies are warranted in this regard.
帕金森病（PD）是一种进行性脑部神经退行性疾病（NDD）。据报道，催乳素（PRL）激素在帕金森病中发挥不同的作用，可能升高、降低或无影响。催乳素水平在包括帕金森病在内的不同神经退行性疾病中失调。临床前和临床研究指出，催乳素可能对帕金森病神经病理学具有神经保护作用。然而，催乳素在帕金森病中的作用机制尚未完全阐明。因此，本综述的目的是阐明催乳素在帕金森病神经病理学中的潜在作用和作用机制途径。本综述强调，催乳素似乎通过抑制促炎信号通路的表达、抗氧化作用和抑制神经炎症，对帕金森病神经病理学具有神经保护作用。因此，在这方面有必要进行临床前和临床研究。
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