波形蛋白是伤口愈合的核心。

Vimentin at the core of wound healing.

作者信息

Coelho-Rato Leila S, Parvanian Sepideh, Modi Mayank Kumar, Eriksson John E

机构信息

Turku Bioscience Centre, University of Turku and Åbo Akademi University, 20520 Turku, Finland; Faculty of Science and Engineering, Cell Biology, Åbo Akademi University, 20520 Turku, Finland.

Turku Bioscience Centre, University of Turku and Åbo Akademi University, 20520 Turku, Finland; Faculty of Science and Engineering, Cell Biology, Åbo Akademi University, 20520 Turku, Finland; Center for Systems Biology, Massachusetts General Hospital Research Institute and Harvard Medical School, Boston, MA 02114, USA.

出版信息

Trends Cell Biol. 2024 Mar;34(3):239-254. doi: 10.1016/j.tcb.2023.08.004. Epub 2023 Sep 23.

DOI:10.1016/j.tcb.2023.08.004

PMID:37748934

Abstract

As a member of the large family of intermediate filaments (IFs), vimentin has emerged as a highly dynamic and versatile cytoskeletal protein involved in many key processes of wound healing. It is well established that vimentin is involved in epithelial-mesenchymal transition (EMT) during wound healing and metastasis, during which epithelial cells acquire more dynamic and motile characteristics. Moreover, vimentin participates in multiple cellular activities supporting growth, proliferation, migration, cell survival, and stress resilience. Here, we explore the role of vimentin at each phase of wound healing, with focus on how it integrates different signaling pathways and protects cells in the fluctuating and challenging environments that characterize a healing tissue.

摘要

作为中间丝（IFs）大家族的一员，波形蛋白已成为一种高度动态且多功能的细胞骨架蛋白，参与伤口愈合的许多关键过程。众所周知，波形蛋白在伤口愈合和转移过程中参与上皮-间质转化（EMT），在此过程中上皮细胞获得更具动态性和迁移性的特征。此外，波形蛋白参与多种支持生长、增殖、迁移、细胞存活和应激恢复力的细胞活动。在这里，我们探讨波形蛋白在伤口愈合各阶段的作用，重点关注它如何整合不同的信号通路，并在愈合组织特有的波动和具有挑战性的环境中保护细胞。