口腔白斑病恶性转化的生物标志物：从基础到临床。
Biomarkers of malignant transformation in oral leukoplakia: from bench to bedside.
机构信息
Department of Oral Pathology, Peking University School and Hospital of Stomatology / National Center of Stomatology / National Clinical Research Center for Oral Diseases / National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing 100081, China.
Research Unit of Precision Pathologic Diagnosis in Tumors of the Oral and Maxillofacial Regions, Chinese Academy of Medical Sciences (2019RU034), Beijing 100081, China.
出版信息
J Zhejiang Univ Sci B. 2023 May 13;24(10):868-882. doi: 10.1631/jzus.B2200589.
Oral leukoplakia is a common precursor lesion of oral squamous cell carcinoma, which indicates a high potential of malignancy. The malignant transformation of oral leukoplakia seriously affects patient survival and quality of life; however, it is difficult to identify oral leukoplakia patients who will develop carcinoma because no biomarker exists to predict malignant transformation for effective clinical management. As a major problem in the field of head and neck pathologies, it is imperative to identify biomarkers of malignant transformation in oral leukoplakia. In this review, we discuss the potential biomarkers of malignant transformation reported in the literature and explore the translational probabilities from bench to bedside. Although no single biomarker has yet been applied in the clinical setting, profiling for genomic instability might be a promising adjunct.
口腔白斑病是口腔鳞状细胞癌的常见前驱病变，提示恶性潜能高。口腔白斑病的恶变严重影响患者的生存和生活质量；然而，由于目前尚无预测恶性转化的生物标志物，因此难以识别可能发生癌变的口腔白斑病患者，无法进行有效的临床管理。作为头颈部病理学领域的一个主要问题，确定口腔白斑病恶变的生物标志物至关重要。在这篇综述中，我们讨论了文献中报道的恶性转化的潜在生物标志物，并探讨了从实验室到临床的转化可能性。虽然目前还没有单一的生物标志物应用于临床，但基因组不稳定性的分析可能是一种很有前途的辅助手段。
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