Janardhana Ranjith D, Jackson Nathan
Department of Mechanical Engineering, University of New Mexico, Albuquerque, NM 87131, USA.
Nanoscience and Microsystems Engineering, University of New Mexico, Albuquerque, NM 87131, USA.
Sensors (Basel). 2023 Oct 8;23(19):8317. doi: 10.3390/s23198317.
The integration of high-frequency acoustic waves with microfluidics has been gaining popularity as a method of separating cells/particles. A standing surface acoustic wave (sSAW) device produces constructive interference of the stationary waves, demonstrating an increase in cell separating efficiency without damaging/altering the cell structure. The performance of an sSAW device depends on the applied input signal, design of the IDT, and piezoelectric properties of the substrate. This work analyzes the characteristics of a validated 3D finite element model (FEM) of LiNbO and the effect on the displacement components of the mechanical waves under the influence of sSAWs by considering XY-, YX-, and 128 YX-cut LiNbO with varying electrode length design. We demonstrated that device performance can be enhanced by the interference of multiple waves under a combination of input signals. The results suggest that 128 YX-cut LiNbO is suitable for generating higher-amplitude out-of-plane waves which can improve the effectiveness of acoustofluidics-based cell separation. Additionally, the findings showed that the length of the electrode impacts the formation of the wavefront significantly.
高频声波与微流体技术的结合作为一种分离细胞/颗粒的方法越来越受到关注。驻表面声波(sSAW)装置会产生驻波的相长干涉,在不破坏/改变细胞结构的情况下提高细胞分离效率。sSAW装置的性能取决于所施加的输入信号、叉指换能器(IDT)的设计以及衬底的压电特性。这项工作通过考虑不同电极长度设计的XY -、YX - 和128 YX切割的铌酸锂,分析了经过验证的铌酸锂三维有限元模型(FEM)的特性以及在sSAW影响下机械波位移分量的变化。我们证明了在输入信号组合下,多波干涉可以提高装置性能。结果表明,128 YX切割的铌酸锂适合产生更高振幅的面外波,这可以提高基于声流体的细胞分离效果。此外,研究结果表明电极长度对波前的形成有显著影响。