认知个体内变异性与老年 HIV 感染者日常生活中的执行功能障碍程度相关。
Cognitive Intra-individual Variability in the Laboratory Is Associated With Greater Executive Dysfunction in the Daily Lives of Older Adults With HIV.
机构信息
Department of Psychology, University of Houston, Houston, Texas.
Michael E. DeBakey VA Medical Center, Houston, Texas.
出版信息
Cogn Behav Neurol. 2024 Mar 1;37(1):32-39. doi: 10.1097/WNN.0000000000000358.
BACKGROUND
Executive dysfunction, which is common among persons with HIV (PWH), can have an adverse impact on health behaviors and quality of life. Intra-individual variability (IIV) is a measure of within-person variability across cognitive tests that is higher in PWH and is thought to reflect cognitive dyscontrol.
OBJECTIVE
To assess whether cognitive IIV in the laboratory is associated with self-reported executive dysfunction in daily life among older PWH.
METHOD
Participants included 71 PWH aged ≥50 years who completed six subtests from the Cogstate battery and two subscales from the Frontal Systems Behavior Scale (FrSBe; self-report version). Cognitive IIV was calculated from the Cogstate as the coefficient of variation derived from age-adjusted normative T scores.
RESULTS
Cognitive IIV as measured by the Cogstate showed a significant, positive, medium-sized association with current FrSBe ratings of executive dysfunction but not disinhibition.
CONCLUSION
Higher cognitive IIV in the laboratory as measured by the Cogstate may be related to the expression of HIV-associated symptoms of executive dysfunction in daily life for older PWH.
背景
执行功能障碍在 HIV 感染者（PWH）中很常见，会对健康行为和生活质量产生不利影响。个体内变异性（IIV）是衡量认知测试中个体内变异性的一种指标，在 PWH 中更高，被认为反映了认知失控。
目的
评估实验室中的认知 IIV 是否与老年 PWH 日常生活中自我报告的执行功能障碍有关。
方法
参与者包括 71 名年龄≥50 岁的 PWH，他们完成了 Cogstate 电池的六个子测试和 FrSBe（自我报告版本）的两个分量表。认知 IIV 是从 Cogstate 中计算出来的，是由年龄调整后的规范 T 分数得出的变异系数。
结果
Cogstate 测量的认知 IIV 与当前 FrSBe 对执行功能障碍的评估呈显著正相关，但与去抑制无关。
结论
Cogstate 测量的实验室中较高的认知 IIV 可能与老年 PWH 日常生活中与 HIV 相关的执行功能障碍症状的表现有关。
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