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营养如何影响奶牛的表观遗传变化?

How Does Nutrition Affect the Epigenetic Changes in Dairy Cows?

作者信息

Lesta Ana, Marín-García Pablo Jesús, Llobat Lola

机构信息

MMOPS Research Group, Departamento Producción y Sanidad Animal, Salud Pública y Ciencia y Tecnología de los Alimentos, Facultad de Veterinaria, Universidad Cardenal Herrera-CEU, CEU Universities, 46115 Valencia, Spain.

Department of Animal Production and Health, Veterinary Public Health and Food Science and Technology (PASAPTA), Facultad de Veterinaria, Universidad Cardenal Herrera-CEU, CEU Universities, 46113 Valencia, Spain.

出版信息

Animals (Basel). 2023 Jun 5;13(11):1883. doi: 10.3390/ani13111883.

Abstract

Dairy cows require a balanced diet that provides enough nutrients to support milk production, growth, and reproduction. Inadequate nutrition can lead to metabolic disorders, impaired fertility, and reduced milk yield. Recent studies have shown that nutrition can affect epigenetic modifications in dairy cows, which can impact gene expression and affect the cows' health and productivity. One of the most important epigenetic modifications in dairy cows is DNA methylation, which involves the addition of a methyl group to the DNA molecule. Studies have shown that the methylation status of certain genes in dairy cows can be influenced by dietary factors such as the level of methionine, lysine, choline, and folate in the diet. Other important epigenetic modifications in dairy cows are histone modification and microRNAs as regulators of gene expression. Overall, these findings suggest that nutrition can have a significant impact on the epigenetic regulation of gene expression in dairy cows. By optimizing the diet of dairy cows, it may be possible to improve their health and productivity by promoting beneficial epigenetic modifications. This paper reviews the main nutrients that can cause epigenetic changes in dairy cattle by analyzing the effect of diet on milk production and its composition.

摘要

奶牛需要均衡的饮食,以提供足够的营养来支持产奶、生长和繁殖。营养不足会导致代谢紊乱、繁殖力受损和产奶量下降。最近的研究表明,营养会影响奶牛的表观遗传修饰,这会影响基因表达并影响奶牛的健康和生产力。奶牛最重要的表观遗传修饰之一是DNA甲基化,它涉及在DNA分子上添加一个甲基基团。研究表明,奶牛某些基因的甲基化状态会受到饮食因素的影响,如日粮中甲硫氨酸、赖氨酸、胆碱和叶酸的水平。奶牛其他重要的表观遗传修饰是组蛋白修饰和作为基因表达调节因子的微小RNA。总体而言,这些发现表明营养对奶牛基因表达的表观遗传调控有重大影响。通过优化奶牛的饮食,有可能通过促进有益的表观遗传修饰来改善它们的健康和生产力。本文通过分析日粮对牛奶产量及其成分的影响,综述了可导致奶牛表观遗传变化的主要营养素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/722a/10251833/9dd01c4d326b/animals-13-01883-g001.jpg

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