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晚期胃癌靶向治疗应用的临床观点

A Clinical Viewpoint on the Use of Targeted Therapy in Advanced Gastric Cancer.

作者信息

Skórzewska Magdalena, Gęca Katarzyna, Polkowski Wojciech P

机构信息

Department of Surgical Oncology, Medical University of Lublin, Radziwiłłowska 13 St., 20-080 Lublin, Poland.

出版信息

Cancers (Basel). 2023 Nov 20;15(22):5490. doi: 10.3390/cancers15225490.

Abstract

The development of therapies for advanced gastric cancer (GC) has made significant progress over the past few years. The identification of new molecules and molecular targets is expanding our understanding of the disease's intricate nature. The end of the classical oncology era, which relied on well-studied chemotherapeutic agents, is giving rise to novel and unexplored challenges, which will cause a significant transformation of the current oncological knowledge in the next few years. The integration of established clinically effective regimens in additional studies will be crucial in managing these innovative aspects of GC. This study aims to present an in-depth and comprehensive review of the clinical advancements in targeted therapy and immunotherapy for advanced GC.

摘要

在过去几年中,晚期胃癌(GC)治疗方法的发展取得了重大进展。新分子和分子靶点的发现正在拓展我们对这种疾病复杂本质的认识。依赖于经过充分研究的化疗药物的经典肿瘤学时代即将结束,这带来了新的、尚未探索的挑战,这些挑战将在未来几年引起当前肿瘤学知识的重大变革。在更多研究中整合已确立的临床有效方案对于应对GC的这些创新方面至关重要。本研究旨在对晚期GC靶向治疗和免疫治疗的临床进展进行深入而全面的综述。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a3c/10670421/0cff7eabb2d6/cancers-15-05490-g001.jpg

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