MCP-1-2518A>G（rs1024611）多态性与 2 型糖尿病及糖尿病肾病易感性的关联：一项荟萃分析。
Association between the MCP-1 -2518 A > G (rs1024611) polymorphism and susceptibility to type 2 diabetes mellitus and diabetic nephropathy: a meta-analysis.
机构信息
Department of Epidemiology and Health Statistics, School of Public Health, Wannan Medical College, Wuhu, Anhui, 241002, China.
Department of Hospital Infection Management Office, Wuhu Hospital of Traditional Chinese Medicine, Wuhu, Anhui, 241000, China.
出版信息
BMC Endocr Disord. 2023 Dec 4;23(1):267. doi: 10.1186/s12902-023-01514-z.
BACKGROUND
Studies evaluating the association between monocyte chemoattractant protein-1 (MCP-1) -2518 A > G (rs1024611) polymorphism and type 2 diabetes mellitus (T2DM) and diabetic nephropathy (DN) are contradictory. The present study aims to provide a comprehensive assessment and more reliable estimation of the relationship between the MCP-1 rs1024611 polymorphism and T2DM and DN risk.
METHODS
Eligible articles were retrieved from the PubMed, Web of Science, EMBASE, Cochrane, and China National Knowledge Infrastructure databases. The effect summary odds ratios (ORs) and 95% confidence intervals (CIs) were obtained to calculate the summary effect size. Heterogeneity was analyzed by subgroup analysis and meta-regression. Publication bias was tested using funnel plots and Egger's test.
RESULTS
In total, sixteen studies were included. Thirteen studies involving 2,363 patients with T2DM and 4,650 healthy controls found no significant association between the MCP-1 rs1024611 polymorphism and T2DM in the overall population. Ethnicity stratification found an association between the GG + GA genotype and decreased T2DM risk in Caucasians (OR = 0.79, 95% CI: 0.66-0.93, P = 0.006; P = 0.372). No significant risks were found in the Asian population for any genetic models. Seven studies found an association between the GG + GA genotype and DN risk in the Asian population (OR = 1.37, 95% CI: 1.11-1.71, P = 0.004, P = 0.222). No significant risks were found in the Caucasian population with any genetic models. There were no statistically significant differences in genotype distribution between patients with T2DM and DN in Asians or Caucasians. Meta-regression revealed that genotyping method was a major driver of heterogeneity in five genetic models (GG + GA vs. AA: P = 0.032; GG vs. GA + AA: P = 0.028; GG vs. AA: P = 0.035; GG vs. GA: P = 0.041; G vs. A: P = 0.041).
CONCLUSION
The MCP-1 rs1024611 polymorphism is associated with susceptibility to T2DM in Caucasians and DN in Asians. Larger, well-designed cohort studies are needed in the future to verify this association.
背景
评估单核细胞趋化蛋白-1（MCP-1）-2518 A>G（rs1024611）多态性与 2 型糖尿病（T2DM）和糖尿病肾病（DN）之间关联的研究结果存在矛盾。本研究旨在提供对 MCP-1 rs1024611 多态性与 T2DM 和 DN 风险之间关系的全面评估和更可靠的估计。
方法
从 PubMed、Web of Science、EMBASE、Cochrane 和中国国家知识基础设施数据库中检索符合条件的文章。使用汇总优势比（OR）和 95%置信区间（CI）来获得效应总结，以计算汇总效应大小。通过亚组分析和 meta 回归分析异质性。使用漏斗图和 Egger 检验测试发表偏倚。
结果
共纳入 16 项研究。其中 13 项研究共纳入 2363 例 T2DM 患者和 4650 例健康对照者，未发现 MCP-1 rs1024611 多态性与总体人群 T2DM 之间存在显著关联。在种族分层中发现，G 等位基因（G 等位基因）与高加索人群 T2DM 风险降低相关（OR=0.79，95%CI：0.66-0.93，P=0.006；P=0.372）。在亚洲人群中，任何遗传模型均未发现 G 等位基因存在显著风险。在亚洲人群中，7 项研究发现 GG+GA 基因型与 DN 风险相关（OR=1.37，95%CI：1.11-1.71，P=0.004，P=0.222）。在高加索人群中，任何遗传模型均未发现 GG+GA 基因型存在显著风险。在亚洲人和高加索人中，T2DM 和 DN 患者的基因型分布无统计学差异。Meta 回归显示，在五个遗传模型中，基因型检测方法是异质性的主要驱动因素（GG+GA 与 AA：P=0.032；GG 与 GA+AA：P=0.028；GG 与 AA：P=0.035；GG 与 GA：P=0.041；G 与 A：P=0.041）。
结论
MCP-1 rs1024611 多态性与高加索人群 T2DM 易感性和亚洲人群 DN 相关。未来需要更大规模、设计良好的队列研究来验证这种关联。
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