Assessing the Probiotic Effects of CACC616 in Weaned Piglets.

During weaning, piglets experience various stressor events that disrupt their gut microbiota and immune balance, decrease growth parameters, and increase mortality rates. In this study, we assessed the efficacy of CACC616 as a probiotic supplement. We characterized this strain and evaluated its effect on improving growth performance, modulating gut microbiota composition, and reducing noxious odor components in weaned piglets compared to a non-supplementary diet (control). During the 26-day period, 40 crossbred weaned piglets were randomly assigned to pens with 20 animals each in two groups: control and treatment groups with CACC616. On day 26, the treatment group exhibited a lower feed conversion ratio (FCR) and a significant alteration in gut microbial composition, correlating with improved growth parameters and gut health ( < 0.05). The treatment group also exhibited significantly reduced digestibility- and intestinal-environment-related noxious odor components ( < 0.05). The CACC616 strain effectively reduced pathogenic genera numbers, including , , and spp., with the treatment group exhibiting lower fecal calprotectin levels than the control group ( < 0.05). Overall, this study revealed that the functional probiotic CACC616 contributes to enhanced FCR and effectively modulates weaned piglets' inflammation and intestinal microbiota.