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随机和观察性尿液药物筛查与阿片类药物治疗项目长期保留的关联。

Association of random and observed urine drug screening with long-term retention in opioid treatment programs.

机构信息

Clinical and Population Health Research Program, Graduate School of Biomedical Sciences University of Massachusetts Chan Medical School, 55 N Lake Ave, Worcester, MA 01655, USA.

Dept. of Medicine, UMass Chan Medical School - Baystate, 759 Chestnut St, Springfield, MA 01199, USA; Epidemiology/Biostatistics Research Core - Baystate Medical Center, Office of Research, 3601 Main Street, Third Floor, Springfield, MA 01199, USA.

出版信息

Drug Alcohol Depend. 2024 Feb 1;255:111067. doi: 10.1016/j.drugalcdep.2023.111067. Epub 2023 Dec 24.

Abstract

BACKGROUND

In the US, opioid treatment providers (OTPs) have wide latitude to perform urine drug screening (UDS) and discharge clients for positive results. OTP clients have identified randomized and directly observed UDS as potentially stigmatizing, but little research has examined the association between UDS modality and retention in OTPs.

METHODS

This cross-sectional study uses the 2016-2017 NDATSS wave among OTPs that administered methadone. The exposure was a 4-level variable based on whether OTPs had a high percentage (≥ 90% of clients) who experienced randomized, observed, both, or neither modality of UDS. The outcome was the proportion of clients retained in treatment 1 year or longer (long-term retention). Analyses were conducted using fractional logit regression with survey weighting and presented as percentages and 95% confidence intervals. We also present how policies for involuntary clinic discharge modify these effects.

RESULTS

150 OTPs were eligible with a median of 310 clients. 40 (27%) OTPs did not highly utilize either randomized or observed UDS, 22 (15%) only highly utilized observed UDS, 42 (28%) only highly utilized randomized UDS and 46 (31%) utilized both practices on ≥ 90% of clients. Adjusted estimates for long-term retention ranged from 57.7% in OTPs that conducted both randomized and observed UDS on ≥ 90% of clients and 70.4% in OTPs that did not highly utilize these practices. Involuntary discharge may moderate this relationship.

CONCLUSION

Findings showed an association between high utilization of randomized and observed UDS and decreased long-term retention, suggesting that UDS modality may impact long-term OTP retention.

摘要

背景

在美国,阿片类药物治疗提供者(OTP)在进行尿液药物筛查(UDS)和因阳性结果而解雇患者方面有很大的自由度。OTP 患者已经确定随机和直接观察 UDS 可能具有污名化,但很少有研究调查 UDS 模式与 OTP 保留率之间的关系。

方法

本横断面研究使用了在 OTP 中管理美沙酮的 2016-2017 年 NDATSS 波。暴露是一个 4 级变量,基于 OTP 是否有高比例(≥90%的患者)经历过随机、观察、两者兼有或两者均无的 UDS 模式。结果是在治疗中保留 1 年或更长时间(长期保留)的患者比例。分析采用带有调查权重的分数对数回归进行,并以百分比和 95%置信区间表示。我们还展示了非自愿诊所出院政策如何改变这些影响。

结果

有 150 个 OTP 符合条件,中位数为 310 名患者。40(27%)个 OTP 没有高度利用随机或观察 UDS,22(15%)个 OTP 只高度利用观察 UDS,42(28%)个 OTP 只高度利用随机 UDS,46(31%)个 OTP 在≥90%的患者中同时使用这两种方法。长期保留的调整估计值范围从在≥90%的患者中同时进行随机和观察 UDS 的 OTP 中的 57.7%到不高度利用这些方法的 OTP 中的 70.4%。非自愿出院可能会调节这种关系。

结论

研究结果表明,高度利用随机和观察 UDS 与长期保留率降低之间存在关联,这表明 UDS 模式可能会影响 OTP 的长期保留率。

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